Apocrine Carcinoma (Apocrine Adenocarcinoma)

 History of breast carcinoma

image May be indistinguishable histologically and immunohistochemically from apocrine carcinoma

• Primary cutaneous adenoid cystic carcinoma
image Cribriform pattern within islands that are relatively uniform in size/shape and not interconnected

image Deeply infiltrative, almost always with perineural invasion

• Tubular apocrine adenoma
image Well circumscribed, noninfiltrative

image Tubular islands with evidence of decapitation secretion

image Islands not crowded together

image Minimal cytologic atypia

image Often myoepithelial cell layer present

• Hidradenocarcinoma
image Larger solid and cystic nodules, infiltrative

image Admixture of cell types: Clear, squamoid, poroid, mucinous

image Hyalinized stroma

Apocrine Carcinoma at Scanning Magnification
Low magnification shows a densely cellular dermal proliferation of packed glands and ductal structures, with many lumina image easily identified.

Apocrine Carcinoma With Prominent Snouts and Secretions
Higher magnification of the ductal/glandular structures shows enlarged, cuboidal to columnar-shaped cells with prominent apical snouts and secretions image, typical of apocrine differentiation.

Apocrine Carcinoma With Perineural Invasion
High-magnification view of apocrine carcinoma with perineural invasion image shows glands lined by cuboidal cells surrounding a nerve. Focal snouts and secretions of cytoplasm image are present within the lumina.

Immunohistochemistry for GCDFP-15
Apocrine carcinoma stains diffusely with GCDFP-15. The islands are crowded together, and lumina image can be seen in many of the islands.



• Cribriform apocrine carcinoma


• Malignant tumor with apocrine differentiation



• Axilla and anogenital regions are most common sites, but other sites described


• Dermal nodule, often asymptomatic

• May present within nevus sebaceus

• No history of breast carcinoma


• Wide local excision; role of chemotherapy or radiotherapy unclear

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Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Apocrine Carcinoma (Apocrine Adenocarcinoma)

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