Antibodies Discussed

Antibody Name/Symbol

Antibody Description

Clones/Alternative Names

Chapters

α1-antichymotrypsin

alpha 1 antichromotrypsin

A1ACT

Myofibroma and Myofibromatosis; PEComas

α-fetoprotein

alpha 1 fetoprotein

AFP, Z5A06, Clone C3

Metastatic Tumors to the Skin

β-2-microglobulin

B2-microglob

Angioimmunoblastic T-cell Lymphoma; Mycosis Fungoides (and Subtypes)

β-catenin

beta catenin; involved in regulation of cell adhesion and in signal transduction through Wnt pathway

B-catenin, CLONE 14, E-5, RB-9035Po, 17C2, 5H10

Digital Fibromatosis (Infantile Digital Fibromatosis); Ectopic Meningioma; Extranodal NK/T-cell Lymphoma, Nasal Type; Fibromatosis; Fibrosarcoma; Juvenile Hyaline Fibromatosis; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Myofibroma and Myofibromatosis; Pilomatrixoma and Pilomatrical Carcinoma; Plexiform Fibrohistiocytic Tumor; Pseudosarcomatous Fibroblastic Proliferations

34bE12

cytokeratin, high molecular weight (34bE12- CK 1, 5, 10, 14)

MA-903, CK903

Toker Cell Hyperplasia

Actin-HHF-35

actin, muscle (HHF35)

MSA, HHF-35

Angiomatoid Fibrous Histiocytoma; Myofibroma and Myofibromatosis; PEComas; Sinonasal Melanoma

Actin-sm

actin, smooth muscle

SMA, ASM-1, CGA7, 1A4, HUC1-1

Adenoid Cystic Carcinoma; Angioleiomyoma; Angiomatoid Fibrous Histiocytoma; Angiosarcoma; Atypical Fibroxanthoma; Bronchogenic Cyst; Cellular Neurothekeoma; Congenital Smooth Muscle Hamartoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Dermatofibroma and Fibrous Histiocytoma; Digital Fibromatosis (Infantile Digital Fibromatosis); Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Hemangioendothelioma; Epithelioid Sarcoma; Glomus Tumors; Infantile Hemangioma; Kaposi Sarcoma; Leiomyosarcoma; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Myxofibrosarcoma; Neuromas; PEComas; Perineurioma; Pleomorphic Fibroma; Pseudosarcomatous Fibroblastic Proliferations; Sinonasal Melanoma; Spindle Cell Hemangioma; Squamous Cell Carcinoma (and Variants)

Adipophilin

ADFP (adipose differentiationrelated protein)

AP125

Hidradenocarcinoma; Hidradenoma

AE1/AE3

mixture of 2 anticytokeratin clones that detect a variety of both high and low molecular weight cytokeratins

Atypical Fibroxanthoma; Congenital Smooth Muscle Hamartoma; Digital Fibromatosis (Infantile Digital Fibromatosis); Epithelioid Sarcoma; Extramammary Paget Disease; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Median Raphe Cyst; Squamomelanocytic Tumor; Syringocystadenoma Papilliferum

ALK

anaplastic lymphoma kinase 1

ALK1, 5A4, ALKC

Atypical Lipomatous Tumor and Liposarcoma; Histiocytic Sarcoma; Lymphomatoid Papulosis; Primary Cutaneous Anaplastic Large Cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

ALK1

anaplastic lymphoma kinase 1

5A4, ALKC

Adult T-cell Leukemia/Lymphoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Primary Cutaneous Anaplastic Large Cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

Androgen receptor

AR441, F39.4.1, AR-N20, ANDROGEN RE

Apocrine Carcinoma (Apocrine Adenocarcinoma); Basal Cell Carcinoma; Hidradenoma; Sebaceous Carcinoma; Squamous Cell Carcinoma (and Variants); Squamous Cell Carcinoma In Situ (Bowen Disease); Tricholemmal Carcinoma

APC

adenomatous polyposis coliprotein

Fibromatosis; Myofibroma and Myofibromatosis

BAD

Bcl-2-associated agonist of cell death

Mucosal Melanoma (Genital)

BAX

Bcl-2-associated X protein

PU-347-P, B-9, BAX-P, P19, BAX-M

Basal Cell Carcinoma

Bcl-1

Cyclin-D1

Systemic B-cell Lymphomas Involving the Skin

Bcl-2

B-cell lymphoma 2; suppresses apoptosis in a variety of cell systems

ONCL2, BCL2/100/D5, 124, 124.3

Actinic Keratosis; Basal Cell Carcinoma; Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Digital Fibromatosis (Infantile Digital Fibromatosis); Inverted Follicular Keratosis; Leukemia Cutis; Lymphomatoid Papulosis; Microcystic Adnexal Carcinoma; Nevus Sebaceus and Follicular Hamartomas; Perineurioma; Primary Cutaneous Follicle Center Lymphoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sebaceous Carcinoma; Systemic B-cell Lymphomas Involving the Skin; Trichoblastoma; Trichoepithelioma

Bcl-6

B-cell CLL/lymphoma 6

LN22, GI191E/A8, N-3, PG-B6P, P1F6, 3FR-1

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Leukemia Cutis; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma

BDCA-2

monoclonal antibody directed toward immature plasmacytoid dendritic cells

CD303

Blastic Plasmacytoid Dendritic Cell Neoplasm

BER-EP4

epithelial cell adhesion molecule

AUA1, VU-1D9, EPCAM, C10, HEA125

Actinic Keratosis; Basal Cell Carcinoma; Hidradenocarcinoma; Hidradenoma; Metastatic Tumors to the Skin; Sebaceoma (Sebaceous Epithelioma); Sebaceous Adenoma; Sebaceous Carcinoma; Squamous Cell Carcinoma (and Variants)

BF1

T-cell receptor antigen

T_Cell_AG_R, Beta-F1, 8A3, TCR

Intravascular Large B-cell Lymphoma

BMI1

B-cell-specific Moloney murine leukemia virus site 1

6C9, F6

Basal Cell Carcinoma

BOB.1

B-cell OCT-binding protein 1

SC955, BOB1

Lymphomatoid Granulomatosis

C-Kit

tyrosine-protein kinase activity

CD117, C-19 (C-KIT), 104D2, 2E4, CKIT, A4502, H300, CMA-767

Cutaneous and Systemic Mastocytosis

c-myc

myelocytomatosis viral oncogene

C-MYC, 9E10, 9E11, 1-262

Atypical Vascular Lesion; Systemic B-cell Lymphomas Involving the Skin

C-reactive protein

Acute phase protein involved in complement activation

CRP

Extranodal NK/T-cell Lymphoma, Nasal Type; Subcutaneous Panniculitis-like T-cell Lymphoma

CA 19-9

related to the Lewis blood group; shown to label multiple types of adenocarcinomas

1116NS19-9

Metastatic Tumors to the Skin

Calcitonin

polypeptide hormone produced by parafollicular cells (C cells) of the thyroid

CALBINDIN28

Metastatic Tumors to the Skin

Caldesmon

actin interacting and calmodulin binding protein found in smooth muscle and other cell types

Digital Fibromatosis (Infantile Digital Fibromatosis); Glomus Tumors; Leiomyosarcoma; Myofibroma and Myofibromatosis; Pseudosarcomatous Fibroblastic Proliferations

Calponin

thin filament-associated protein that is implicated in regulation and modulation of smooth muscle contraction

N3, 26A11, CALP, CNN1, SMCC, Sm Calp

Adenoid Cystic Carcinoma; Angiomatoid Fibrous Histiocytoma; Chondroid Lipoma; Cutaneous Mixed Tumor (Chondroid Syringoma); Cylindroma; Digital Fibromatosis (Infantile Digital Fibromatosis); Fibromatosis; Leiomyoma (Pilar); Leiomyosarcoma; Malignant Mixed Tumor; Myofibroma and Myofibromatosis; PEComas; Pseudosarcomatous Fibroblastic Proliferations; Spiradenoma

Calretinin

29 kDa calcium binding protein that is expressed in central and peripheral nervous system and in many normal and pathological tissues

DAK-CALRET, 5A5, CAL 3F5, DC8, AB149

Granular Cell Tumor; Metastatic Tumors to the Skin

Carcinooembryonic antigen

CEA-M, mCEA, CEA-B18, CEA-D14, CEAGOLD 1, T84.6, CEA-GOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEAGOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEA-M, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEA-M431_31, CEJO65

Clear Cell Papulosis; Cutaneous Mixed Tumor (Chondroid Syringoma); Papillary Eccrine Adenoma

CCND1

protein with important cell cycle regulatory functions

Cyclin-D1, bcl-1 (cyclin D1) A-12, PRAD1, AM29, DCS-6, SP4, 5D4, D1GM, P2D11F11, CCND1, Cyl-1

Systemic B-cell Lymphomas Involving the Skin

CCR4

chemokine receptor 4

CD194

Leukemia Cutis

CD1a

T-cell surface glycoprotein

JPM30, CD1A, O10, NA1/34

Blastic Plasmacytoid Dendritic Cell Neoplasm; Histiocytic Sarcoma; Juvenile and Adult-type Xanthogranuloma; Langerhans Cell Histiocytosis; Leukemia Cutis; Multicentric Reticulohistiocytosis; Non-Langerhans Cell Histiocytoses; Polyvinylpyrrolidone Storage Disease; Reticulohistiocytoma; Rosai-Dorfman Disease

CD2

T-cell surface antigen

271, MT910, AB75, LFA-2

Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous and Systemic Mastocytosis; Cutaneous Gamma-Delta T-cell Lymphoma; Histiocytic Sarcoma; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD3

T-cell receptor

F7238, A0452, CD3-P, CD3-M, SP7, PS1

Adult T-cell Leukemia/Lymphoma; Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Angiosarcoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Cutaneous Marginal Zone B-cell Lymphoma; Extramammary Paget Disease; Extranodal NK/T-cell Lymphoma, Nasal Type; Histiocytic Sarcoma; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Lymphomatoid Granulomatosis; Lymphomatoid Papulosis; Non-Langerhans Cell Histiocytoses; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Reticulohistiocytoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD3-ε

T-cell surface antigen T3/Leu-4 epsilon chain

CD3E, CD3e

Extranodal NK/T-cell Lymphoma, Nasal Type

CD4

T-cell surface glycoprotein L3T4

IF6, 1290, 4B12, CD4

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Extramammary Paget Disease; Histiocytic Sarcoma; Leukemia Cutis; Lymphomatoid Granulomatosis; Lymphomatoid Papulosis; Mycosis Fungoides (and Subtypes); Non-Langerhans Cell Histiocytoses; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD5

T-cell surface glycoprotein Leu1, T1

NCL-CD5, 4C7, 54/B4, 54/F6

Adult T-cell Leukemia/Lymphoma; Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous Gamma-Delta T-cell Lymphoma; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic B-cell Lymphomas Involving the Skin; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD7

T-cell antigen precursor Leu 9

272, CD7-272

Adult T-cell Leukemia/Lymphoma; Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Intravascular large B-cell Lymphoma; Leukemia Cutis; Lymphomatoid Granulomatosis; Lymphomatoid Papulosis; Mycosis Fungoides (and Subtypes); Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD8

T-cell coreceptor antigen Leu 2, T-cytotoxic cells

M7103, C8/144, C8/144B

Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous Gamma-Delta T-cell Lymphoma; Extramammary Paget Disease; Extranodal NK/T-cell Lymphoma, Nasal Type; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Lymphomatoid Papulosis; Mycosis Fungoides (and Subtypes); Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD9

motility-related protein-1 (MRP-1)

72F16, BA-2

Cutaneous and Systemic Mastocytosis

CD10

neutral endopeptidase

NCL-270, CALLA, neprilysin, neutral endopeptidase, NEP

Adult T-cell Leukemia/Lymphoma; Angioimmunoblastic T-cell Lymphoma; Atypical Fibroxanthoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Cutaneous Plasmacytoma; Dermatofibroma and Fibrous Histiocytoma; Dermatofibrosarcoma Protuberans; Diffuse Large B-cell Lymphoma, Leg Type; Hidradenocarcinoma; Hidradenoma; Leiomyosarcoma; Leukemia Cutis; Metastatic Tumors to the Skin; PEComas; Pleomorphic Fibroma; Primary Cutaneous Follicle Center Lymphoma; Sebaceous Carcinoma; Squamous Cell Carcinoma (and Variants); Systemic B-cell Lymphomas Involving the Skin; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD13

plays role in growth of DC/macrophage progenitors and precursors

Extramedullary Hematopoiesis; Histiocytic Sarcoma

CD14

coreceptor for lipopolysaccharide binding protein

FMC32

Cutaneous and Systemic Mastocytosis; Histiocytic Sarcoma; Non-Langerhans Cell Histiocytoses

CD15

reacts with Reed-Sternberg cells of Hodgkin lymphoma and with granulocytes

VIM-2,3C4, LEU-M1, TU9, VIM-D5, MY1, CBD1, MMA, 3CD1, C3D1, Lewis x, SSEA-1

Cutaneous and Systemic Mastocytosis; Extramedullary Hematopoiesis; Histiocytic Sarcoma; Langerhans Cell Histiocytosis; Lymphomatoid Papulosis; Myxoinflammatory Fibroblastic Sarcoma; Systemic B-cell Lymphomas Involving the Skin

CD16

Fc receptor of IgG found on the surfaces of natural killer cells, neutrophils, monocytes, and macrophages

Cutaneous and Systemic Mastocytosis; Intravascular Large B-cell Lymphoma

CD19

B-cell antigen

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Intravascular large B-cell Lymphoma; Leukemia Cutis; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

CD20

activated-glycosylated phosphoprotein expressed on the surface of B cells from late pro-B cells through memory B cells

FB1, B1, L26

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Cutaneous Plasmacytoma; Diffuse Large B-cell Lymphoma, Leg Type; Extranodal NK/T-cell Lymphoma, Nasal Type; Histiocytic Sarcoma; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Lymphomatoid Granulomatosis; Lymphomatoid Papulosis; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Reticulohistiocytoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic B-cell Lymphomas Involving the Skin; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD21

CR2, complement component receptor 2, Epstein-Barr virus receptor

Adult T-cell Leukemia/Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous Marginal Zone B-cell Lymphoma; Cutaneous Plasmacytoma; Diffuse Large B-cell Lymphoma, Leg Type; Histiocytic Sarcoma; Primary Cutaneous Follicle Center Lymphoma; Rosai-Dorfman Disease; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD22

B-cell receptor

FPC1, LEU 14

Cutaneous Marginal Zone B-cell Lymphoma; Intravascular Large B-cell Lymphoma

CD23

Fc ε RII, low-affinity IgE receptor, IGEBF

1B12, MHM6BU38

Angioimmunoblastic T-cell Lymphoma; Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Histiocytic Sarcoma; Leukemia Cutis; Primary Cutaneous Follicle Center Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD25

IL-2 receptor alpha

2A3, 4C9

Adult T-cell Leukemia/Lymphoma; Cutaneous and Systemic Mastocytosis; Leukemia Cutis; Lymphomatoid Papulosis; Mycosis Fungoides (and Subtypes)

CD26

ADA adenosine deaminase complexing protein 2, DPP4

44-4

Leukemia Cutis; Mycosis Fungoides (and Subtypes)

CD29

fibronectin receptor, integrein beta 1

ITGB1, 29C03, 7F10, HT29_12938

Intravascular Large B-cell Lymphoma

CD30

tumor necrosis factor SF8

BER-H2, KI-1, TNFRSF8

Adult T-cell Leukemia/Lymphoma; Angiomatoid Fibrous Histiocytoma; Angiosarcoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Histiocytic Sarcoma; Leukemia Cutis; Lymphomatoid Papulosis; Mycosis Fungoides (and Subtypes); Myxoinflammatory Fibroblastic Sarcoma; Primary Cutaneous Anaplastic Large Cell Lymphoma; Systemic B-cell Lymphomas Involving the Skin; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD31

platelet endothelial cell adhesion molecule

JC/70, JC/70A, PECAM-1

Angiolymphoid Hyperplasia with Eosinophilia; Angiomatoid Fibrous Histiocytoma; Angiosarcoma; Atypical Fibroxanthoma; Dermal Nerve Sheath Myxoma; Dermatofibroma and Fibrous Histiocytoma; Epithelioid Hemangioendothelioma; Epithelioid Sarcoma; Infantile Hemangioma; Kaposi Sarcoma; Kaposiform Hemangioendothelioma; Lymphangioma and Superficial Lymphangioma; Melanoma, Superficial Spreading Type; Multinucleate Cell Angiohistiocytoma; Papillary Intralymphatic Angioendothelioma (Dabska Tumor); Progressive Lymphangioma; Pseudosarcomatous Fibroblastic Proliferations; Retiform Hemangioendothelioma; Spindle Cell and Pleomorphic Lipoma; Superficial Malignant Peripheral Nerve Sheath Tumor; Vascular Hamartomas

CD33

SIGLEC lectin 3

PWS44

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous and Systemic Mastocytosis; Extramedullary Hematopoiesis; Histiocytic Sarcoma; Leukemia Cutis

CD34

hematopoietic progenitor cell antigen

MY10, IOM34, QBEND10, 8G12, 1309, HPCA-1, NU-4A1, TUK4, clone 581, BI-3c5

Acral Fibrokeratoma; Angiofibroma and Related Lesions; Angioleiomyoma; Angiolymphoid Hyperplasia with Eosinophilia; Angiomatoid Fibrous Histiocytoma; Angiomyofibroblastoma; Angiosarcoma; Atypical Fibroxanthoma; Atypical Lipomatous Tumor and Liposarcoma; Childhood Melanoma; Collagenous Fibroma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Dermal Nerve Sheath Myxoma; Dermatofibroma and Fibrous Histiocytoma; Dermatofibrosarcoma Protuberans; Dermatomyofibroma; Digital Fibromatosis (Infantile Digital Fibromatosis); Distinctive Dermal Clear Cell Mesenchymal Tumor; Eccrine Hamartomas; Ectopic Meningioma; Epithelioid Hemangioendothelioma; Epithelioid Histiocytoma; Epithelioid Sarcoma; Extramedullary Hematopoiesis; Fibromatosis; Fibrosarcoma; Fibrous Hamartoma of Infancy; Glomus Tumors; Granular Cell Tumor; Hibernoma; Infantile Hemangioma; Kaposi Sarcoma; Kaposiform Hemangioendothelioma; Leiomyosarcoma; Leukemia Cutis; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Lymphangioma and Superficial Lymphangioma; Multinucleate Cell Angiohistiocytoma; Myofibroma and Myofibromatosis; Myxofibrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Neurofibroma; Neuromas; Nevus Sebaceus and Follicular Hamartomas; Non-Langerhans Cell Histiocytoses; Papillary Intralymphatic Angioendothelioma (Dabska Tumor); Perineurioma; Pleomorphic Fibroma; Plexiform Fibrohistiocytic Tumor; Progressive Lymphangioma; Pseudosarcomatous Fibroblastic Proliferations; Reticulohistiocytoma; Retiform Hemangioendothelioma; Sclerotic Fibroma; Spindle Cell and Pleomorphic Lipoma; Spindle Cell Hemangioma; Superficial Acral Fibromyxoma; Verrucous Hemangioma

CD35

erythrocyte complement receptor 1, CR1, immune adherence receptor, C3b/C4b receptor

BER-MAC-DRC, TO5, CD35, E11

Angioimmunoblastic T-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Histiocytic Sarcoma; Primary Cutaneous Follicle Center Lymphoma; Rosai-Dorfman Disease; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CD43

Major sialoglycoprotein on surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes

LEU-22, DF-T1, L60, MT1, sialophorin, leukosialin, SPN

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Extramedullary Hematopoiesis; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

CD44

cell adhesion receptor for hyaluronic acid

HCAM, CD44H, B-F24, A3D8, 2C5, CD44S, F10-44.2, 156-3C11, DF1485, BBA10, VFF-14, CD44V10, CD44V3, 3G5, CD44V3-10-P, CD44V3-10, 3D2, CD44V4_5, CD44V5,VFF-8, VFF-7, 2F10, VFF-18, CD44V6, CD44V7, VFF-9, CD44V7_8, VFF-17

Primary Neuroendocrine (Merkel Cell) Carcinoma

CD45

leukocyte common antigen

LCA, PD7/26, 1.22/4.14, T29/33, RP2/18, PD7, 2D1, 2B11+PD7/26

Angiomatoid Fibrous Histiocytoma; Cutaneous and Systemic Mastocytosis; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Extramammary Paget Disease; Giant Cell Tumor of Tendon Sheath; Leukemia Cutis; Multicentric Reticulohistiocytosis; Myxoinflammatory Fibroblastic Sarcoma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Primary Neuroendocrine (Merkel Cell) Carcinoma; Spiradenoma; Extramammary Paget Disease; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

CD45RA

isoform of CD45 expressed by naive T cells

4KB5, MT2, CD45RA, MB1

Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia Cutis

CD45RB

isoform of CD45 expressed by naive and memory T cells

Extramedullary Hematopoiesis; Non-Langerhans Cell Histiocytoses; Oral Melanoma; Sinonasal Melanoma

CD45RO

isoform of CD45 located on memory T cells

ICH1-L, low molecular weight isoform LCA

Leukemia Cutis

CD54

ICAM-1 (intracellular adhesion molecule 1)

23G12, CD54-P, ICAM

Intravascular Large B-cell Lymphoma

CD56

NCAM (neutral cellular adhesion molecule)

MAB735, ERIC-1, 25-KD11, 123C3, 24-MB2, BC56C04, 1B6, 14-MAB735, NCC-LU-243, MOC-1, NCAM

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Lymphomatoid Granulomatosis; Lymphomatoid Papulosis; Neuromas; Sinonasal Melanoma; Subcutaneous Panniculitis-like T-cell Lymphoma

CD57

β-1,3-glucuronyl transferase 1 (glucuronosyl transferase P)

LEU-7, NK1, HNK-1, TB01, B3GAT1

Granular Cell Tumor; Intravascular Large B-cell Lymphoma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Schwannoma (Neurilemmoma)

CD61

cluster of differentiation found on thrombocytes corresponding to glycoprotein IIb/IIIa

Integrin, beta 3 (platelet glycoprotein IIIa), ITGB3, GP3A, GPIIIa, Y2/5, HPA

Extramedullary Hematopoiesis

CD63

tetraspan intracellular granule protein

NKI/C3, basophil activation test in allergy

Cellular Neurothekeoma; Plexiform Fibrohistiocytic Tumor

CD64

Fc receptor for IgG antibodies, high affinity

HAM56

Reticulohistiocytoma

CD68

cytoplasmic granule protein of monocytes, macrophages

PG-M1, KP-1, LN5

Angiofibroma and Related Lesions; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Atypical Lipomatous Tumor and Liposarcoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cellular Neurothekeoma; Chondroid Lipoma; Cutaneous and Systemic Mastocytosis; Dermal Nerve Sheath Myxoma; Dermatofibroma and Fibrous Histiocytoma; Dermatofibrosarcoma Protuberans; Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Histiocytoma; Giant Cell Tumor of Tendon Sheath; Granular Cell Tumor; Histiocytic Sarcoma; Juvenile and Adult-type Xanthogranuloma; Langerhans Cell Histiocytosis; Leiomyosarcoma; Leukemia Cutis; Multicentric Reticulohistiocytosis; Multinucleate Cell Angiohistiocytoma; Myxoinflammatory Fibroblastic Sarcoma; Non-Langerhans Cell Histiocytoses; Pleomorphic Fibroma; Plexiform Fibrohistiocytic Tumor; Polyvinylpyrrolidone Storage Disease; Pseudosarcomatous Fibroblastic Proliferations; Reticulohistiocytoma; Rosai-Dorfman Disease; Squamous Cell Carcinoma (and Variants)

CD79a

immunoglobulin-associated alpha, MB1

MB-1, 11D10, 11E3, CD79A, HM47/A9, HM57, JCB117, CD79-a, CD79-α

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Intravascular large B-cell Lymphoma; Leukemia Cutis; Lymphomatoid Granulomatosis; Primary Cutaneous Follicle Center Lymphoma; Sinonasal Melanoma

CD99

cell surface glycoprotein for migration, T-cell adhesion, MIC2

CD99-MEMB, 12E7, HBA71, O13, P30/32MIC2, M3601

Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Cutaneous Rhabdomyosarcoma; Digital Fibromatosis (Infantile Digital Fibromatosis); Epithelioid Sarcoma; Leiomyosarcoma; Leukemia Cutis; Metastatic Tumors to the Skin; Perineurioma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Pleomorphic Fibroma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sinonasal Melanoma; Squamous Cell Carcinoma (and Variants)

CD117

C-Kit, tyrosine-protein kinase activity

C-19 (C-KIT), 104D2, 2E4, C-KIT, A4502, H300, CMA-767

Angiosarcoma; Cutaneous and Systemic Mastocytosis; Cutaneous Plasmacytoma; Fibromatosis; Leukemia Cutis; Myxoinflammatory Fibroblastic Sarcoma; Oral Melanoma; PEComas; Sinonasal Melanoma

CD123

receptor for IL-3 (IL-3R)

Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia Cutis

CD138

syndecan; a useful marker for plasma cells

B-B4, AM411-10M, MI15

Cutaneous Plasmacytoma; Sinonasal Melanoma; Systemic B-cell Lymphomas Involving the Skin

CD163

macrophage hemoglobin scavenging system

10D6

Dermatofibroma and Fibrous Histiocytoma; Dermatofibrosarcoma Protuberans; Histiocytic Sarcoma; Myxoinflammatory Fibroblastic Sarcoma; Non-Langerhans Cell Histiocytoses; Plexiform Fibrohistiocytic Tumor; Polyvinylpyrrolidone Storage Disease; Reticulohistiocytoma

CD303

monoclonal antibody directed toward immature plasmacytoid dendritic cells

BDCA-2

Leukemia Cutis

CDK4

cyclin dependant kinase 4

C-22, DCS-31

Atypical Lipomatous Tumor and Liposarcoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Hibernoma; PEComas; Spindle Cell and Pleomorphic Lipoma

CDX-2

caudal type homeobox transcription factor 2

AMT28, 7C7/D4, CDX-2-88

Extramammary Paget Disease; Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Metastatic Tumors to the Skin; Primary Cutaneous Mucinous Carcinoma

CEA-M

carcinoembryonic antigen, monoclonal

CEA-B18, CEA-D14, CEA-GOLD 1, T84.6, CEA-GOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEA-GOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEA-M, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEA-M431_31, CEJO65, mCEA

Adenoid Cystic Carcinoma; Hidradenocarcinoma; Porocarcinoma; Sebaceous Carcinoma; Squamoid “Eccrine” Ductal Carcinoma

Chromogranin-A

pituitary secretory protein 1

PHE-5, PHE5, E001, DAK-A3

Dermal Nerve Sheath Myxoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sinonasal Melanoma

Chymase

serine protease found in mast cells and basophils; acts as a mediator of inflammation

Cutaneous and Systemic Mastocytosis

Chymotrypsin

digestive enzyme synthesized in pancreas, involved in proteolysis

Dermatofibrosarcoma Protuberans

CK-HMW-NOS

cytokeratin high molecular weight, not otherwise specified

CK-HMW, HMWCK, 34bE12, CK903

Atypical Fibroxanthoma; Porocarcinoma; Poroma and Dermal Duct Tumor; Squamous Cell Carcinoma (and Variants)

CK-PAN

cytokeratin-pan (AE1/AE3/LP34); cocktail of high and low molecular weight cytokeratins

keratin pan, MAK-6, K576, LU-5, KL-1, KC-8, MNF 116, pankeratin, pancytokeratin

Angiosarcoma; Atypical Fibroxanthoma; Basal Cell Carcinoma; Cutaneous Rhabdomyosarcoma; Epithelioid Hemangioendothelioma; Epithelioid Sarcoma; Glomus Tumors; Granular Cell Tumor; Leiomyosarcoma; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Malignant Mixed Tumor; Myofibroma and Myofibromatosis; Neuromas; Oral Melanoma; PEComas; Perineurioma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sinonasal Melanoma; Squamomelanocytic Tumor; Squamous Cell Carcinoma (and Variants)

CK5/6

cytokeratin 5/6, high molecular weight cytokeratins

D5/16 B4

Atypical Fibroxanthoma; Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Sarcoma; Extramammary Paget Disease; Leiomyosarcoma; Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Malignant Mixed Tumor; Porocarcinoma; Poroma and Dermal Duct Tumor; Primary Cutaneous Mucinous Carcinoma; Sebaceous Carcinoma; Spiradenoma; Squamoid “Eccrine” Ductal Carcinoma; Squamous Cell Carcinoma (and Variants); Squamous Cell Carcinoma In Situ (Bowen Disease); Syringocystadenoma Papilliferum

CK7

cytokeratin 7, low molecular weight cytokeratin

K72.7, KS7.18, OVTL 12/30, LDS-68, CK 07

Clear Cell Papulosis; Cutaneous Ciliated Cyst; Cylindroma; Epithelioid Sarcoma; Extramammary Paget Disease; Histiocytic Sarcoma; Median Raphe Cyst; Melanoma In Situ, Superficial Spreading Type; Metastatic Tumors to the Skin; Microcystic Adnexal Carcinoma; Mucosal Melanoma (Genital); Primary Cutaneous Mucinous Carcinoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sebaceous Carcinoma; Squamoid “Eccrine” Ductal Carcinoma; Squamous Cell Carcinoma In Situ (Bowen Disease); Toker Cell Hyperplasia; Tricholemmal Carcinoma

CK8/18/CAM5.2

cytokeratin 8/18; simple epithelialtype cytokeratins

5D3, Zym5.2, CAM 5.2, KER 10.11, NCL-5D3, cytokeratin LMW

Angiomatoid Fibrous Histiocytoma; Epithelioid Sarcoma; Primary Neuroendocrine (Merkel Cell) Carcinoma

CK10

cytokeratin 10

LHP1, DE-K10, RKSE60

Vellus Hair Cyst

CK13

cytokeratin 13

KS13.1, KS-1A3, AE8, 2D7

Median Raphe Cyst

CK17

cytokeratin 17

E3

Squamoid “Eccrine” Ductal Carcinoma; Vellus Hair Cyst

CK19

cytokeratin 19, low molecular weight cytokeratin

BA17, RCK108, LP2K, B170, A53-BA2, KS19.1, 170.2.14

Cylindroma; Epithelioid Sarcoma

CK20

cytokeratin 20, low molecular weight cytokeratin

KS20.8

Basal Cell Carcinoma; Cutaneous Ciliated Cyst; Cutaneous Rhabdomyosarcoma; Dermatofibroma and Fibrous Histiocytoma; Epithelioid Sarcoma; Extramammary Paget Disease; Leukemia Cutis; Median Raphe Cyst; Metastatic Skin Tumors; Metastatic Tumors to the Skin; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Primary Cutaneous Mucinous Carcinoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sebaceous Carcinoma; Spiradenoma; Squamous Cell Carcinoma In Situ (Bowen Disease); Toker Cell Hyperplasia; Trichoblastoma; Trichoepithelioma

CK903

cytokeratin-HMW, not otherwise specified

CK-HMW, CK-HMW-NOS, HMWCK, 34bE12

Atypical Fibroxanthoma; Distinctive Dermal Clear Cell Mesenchymal Tumor; Leiomyosarcoma; Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Squamous Cell Carcinoma (and Variants)

CLA

cutaneous lymphocyte antigen

Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia Cutis; Systemic T-cell and NK-cell Lymphomas Involving the Skin

Claudin-1

senescence-associated epithelial membrane protein

JAD.8

Ectopic Meningioma; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Perineurioma

Clusterin

clusterin, alpha chain specific

41D, E5

Angioimmunoblastic T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

Collagen II

major component of articular and hyaline cartilage

2B1.5

Cutaneous Mixed Tumor (Chondroid Syringoma)

Collagen IV

major constituent of the basement membranes along with laminins, proteoglycans, and enactins

CIV22, COL4A [1-5], collagen α-1(IV) chain

Cutaneous Mixed Tumor (Chondroid Syringoma); Glomus Tumors; Granular Cell Tumor; Perineurioma; Schwannoma (Neurilemmoma)

Cutaneous lymphocyte antigen

skin homing receptor

CLA

Leukemia Cutis; Primary Cutaneous Anaplastic Large Cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CXCL13

chemokine CXC ligand 13, B lymphocyte chemoattractant

BCA-1, BLC, BLR1L, ANGIE, CXC chemokine BCL, SCYB13

Adult T-cell Leukemia/Lymphoma; Angioimmunoblastic T-cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

CXCR3

chemokine CXC receptor R3

1C6

Intravascular large B-cell Lymphoma

Cyclin-D1

protein with important cell cycle regulatory functions

bcl-1 (cyclin D1) A-12, PRAD1, AM29, DCS-6, SP4, 5D4, D1GM, P2D11F11, CCND1Cyl-1

Chondroid Lipoma; Epithelioid Sarcoma; Primary Dermal Melanoma; Systemic B-cell Lymphomas Involving the Skin

Cytokeratin

Atypical Fibroxanthoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Childhood Melanoma; Chondroid Lipoma; Clear Cell Papulosis; Cutaneous Marginal Zone B-cell Lymphoma; Cutaneous Mixed Tumor (Chondroid Syringoma); Cutaneous Rhabdomyosarcoma; Epithelioid Hemangioendothelioma; Epithelioid Sarcoma; Extramammary Paget Disease; Fibromatosis; Glomus Tumors; Hidradenocarcinoma; Histiocytic Sarcoma; Metastatic Skin Tumors; Metastatic Tumors to the Skin; Oral Melanoma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Pilomatrixoma and Pilomatrical Carcinoma; Plexiform Fibrohistiocytic Tumor; Polyvinylpyrrolidone Storage Disease; Porocarcinoma; Sebaceous Adenoma; Squamomelanocytic Tumor; Syringofibroadenoma; Trichoblastoma; Vellus Hair Cyst

Cytokeratin 5/6

high molecular weight cytokeratins

D5/16 B4

Hidradenocarcinoma; Metastatic Tumors to the Skin

Cytokeratin 7

low molecular weight cytokeratin

K72.7, KS7.18, OVTL 12/30, LDS-68, CK 07

Metastatic Tumors to the Skin; Sebaceous Adenoma

Cytokeratin 20

low molecular weight cytokeratin

KS20.8

Metastatic Tumors to the Skin; Pilomatrixoma and Pilomatrical Carcinoma; Trichoblastoma

D2-40

reacts with an O-linked sialoglycoprotein found on lymphatic endothelium

podoplanin, M2A

Lymphangioma and Superficial Lymphangioma; Metastatic Tumors to the Skin; Papillary Intralymphatic Angioendothelioma (Dabska Tumor); Primary Dermal Melanoma; Progressive Lymphangioma; Retiform Hemangioendothelioma; Rosai-Dorfman Disease; Sebaceous Carcinoma; Squamous Cell Carcinoma (and Variants)

Desmin

class III intermediate filaments found in muscle cells

M760, DE-R-11, D33, DE5, DE-U-10, ZC18

Acral Fibrokeratoma; Angioleiomyoma; Angiomatoid Fibrous Histiocytoma; Angiomyofibroblastoma; Angiosarcoma; Atypical Fibroxanthoma; Childhood Melanoma; Collagenous Fibroma; Congenital Smooth Muscle Hamartoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Cutaneous Rhabdomyosarcoma; Dermal Nerve Sheath Myxoma; Dermatofibrosarcoma Protuberans; Dermatomyofibroma; Digital Fibromatosis (Infantile Digital Fibromatosis); Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Sarcoma; Fibromatosis; Fibrous Hamartoma of Infancy; Giant Cell Tumor of Tendon Sheath; Glomus Tumors; Granular Cell Tumor; Hibernoma; Leiomyoma (Pilar); Leiomyosarcoma; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Myofibroma and Myofibromatosis; Oral Melanoma; Papillary Endothelial Hyperplasia (Masson Tumor); Paraganglioma-like Dermal Melanocytic Tumor; PEComas; Perineurioma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Plexiform Fibrohistiocytic Tumor; Pseudosarcomatous Fibroblastic Proliferations; Reticulohistiocytoma; Rhabdomyoma; Schwannoma (Neurilemmoma); Sinonasal Melanoma; Squamous Cell Carcinoma (and Variants); Superficial Malignant Peripheral Nerve Sheath Tumor

E-cadherin

epithelial calcium dependent adhesion molecule

36B5, ECH-6, ECCD-2, CDH1, 5H9, NCH 38, Clone 36, 4A2 C7, E9, 67A4, HECD-1, SC-8426

Granular Cell Tumor

E2A

Anti-TCF3, TCF3, immunoglobulin enhancerbinding factor E12/E47

Primary Cutaneous Follicle Center Lymphoma

EBER

Epstein-Barr virus encoded RNA

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Plasmacytoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Histiocytic Sarcoma; Leiomyosarcoma; Lymphomatoid Granulomatosis; Systemic T-cell and NK-cell Lymphomas Involving the Skin

EGFR

v-erb b1 erythroblastic leukemia viral gene, epidermal growth factor receptor

2-18C9, EGFR1, EGFR PHRMDX, NCL-R1, H11, C-ERBB-1, E30, EGFR.113, 31G73C6, 2-18C9

Myxoinflammatory Fibroblastic Sarcoma

EMA

epithelial membrane antigen

GP1.4, 214D4, MC5, E29, LICRLON- M8, BC3, DF3, VU3D1, MUSEII, RD-1, MA695, MA552, PS2P446, 115D8, MUC1, MAM6, CA15.3, MUC01

Acral Fibrokeratoma; Adenoid Cystic Carcinoma; Angiosarcoma; Apocrine Tubular Adenoma; Atypical Fibroxanthoma; Basal Cell Carcinoma; Cellular Neurothekeoma; Chondroid Lipoma; Cutaneous Ciliated Cyst; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Cutaneous Mixed Tumor (Chondroid Syringoma); Cutaneous Myxoma and Angiomyxoma; Cutaneous Rhabdomyosarcoma; Cylindroma; Dermal Nerve Sheath Myxoma; Digital Fibromatosis (Infantile Digital Fibromatosis); Eccrine Carcinoma; Eccrine Hamartomas; Ectopic Meningioma; Epithelioid Hemangioendothelioma; Epithelioid Sarcoma; Fibromatosis; Granular Cell Tumor; Hidradenocarcinoma; Hidradenoma; Histiocytic Sarcoma; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Lymphoepitheliomalike Carcinoma of the Skin (LELCS); Melanoma In Situ, Superficial Spreading Type; Microcystic Adnexal Carcinoma; Myxoinflammatory Fibroblastic Sarcoma; Nasal Glial Heterotopia; Neurofibroma; Neuromas; Papillary Eccrine Adenoma; Perineurioma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Porocarcinoma; Primary Cutaneous Anaplastic Large Cell Lymphoma; Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma; Sinonasal Melanoma; Spiradenoma; Squamoid “Eccrine” Ductal Carcinoma; Squamous Cell Carcinoma (and Variants); Squamous Cell Carcinoma In Situ (Bowen Disease); Superficial Acral Fibromyxoma; Syringocystadenoma Papilliferum; Syringoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin; Toker Cell Hyperplasia; Trichoblastoma; Tricholemmal Carcinoma

EMA/MUC1

epithelial membrane antigen

EMA, GP1.4, 214D4, MC5, E29, LICRLON-M8, BC3, DF3, VU3D1, MUSEII, RD-1, MA695, MA552, PS2P446, 115D8, MUC1, MAM6, CA15.3, MUC01

Angiomatoid Fibrous Histiocytoma; Congenital Smooth Muscle Hamartoma; Epithelioid Sarcoma; Extramammary Paget Disease; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Myxofibrosarcoma; Neurofibroma; Perineurioma; Superficial Acral Fibromyxoma

EpCam/BER-EP4/CD326

epithelial cell adhesion molecule

AUA1, VU-1D9, EPCAM, C10, HEA125, BEREP4

Basal Cell Carcinoma; Primary Neuroendocrine (Merkel Cell) Carcinoma

Epithelial membrane antigen

EMA, GP1.4, 214D4, MC5, E29, LICRLON-M8, BC3, DF3, VU3D1, MUSEII, RD-1, MA695, MA552, PS2P446, 115D8, MUC1, MAM6, CA15.3, MUC01

Clear Cell Papulosis; Cutaneous Mixed Tumor (Chondroid Syringoma); Ectopic Meningioma; Fibrolipomatous Hamartoma of Nerve; Oral Melanoma; Papillary Eccrine Adenoma

ER

estrogen receptor protein

1D5, 6F11, SP1, 15D, H222, TE111, ERP, ER1D5, NCLER611, NCL-ER-LH2, PGP-1A6

Angiomyofibroblastoma; Apocrine Carcinoma (Apocrine Adenocarcinoma); Metastatic Tumors to the Skin; Primary Cutaneous Mucinous Carcinoma

ERP

estrogen receptor protein

1D5, 6F11, SP1, 15D, H222, TE111, ER, ER1D5, NCLER611, NCL-ER-LH2, PGP-1A6

Leiomyosarcoma; Primary Cutaneous Mucinous Carcinoma

Factor XIIIa

fibrin stabilizing factor

FXIIIA

Angiofibroma and Related Lesions; Juvenile and Adult-type Xanthogranuloma; Leiomyosarcoma; Non-Langerhans Cell Histiocytoses

FAS

fatty acid synthase

CD95/fas

Cutaneous Marginal Zone B-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type

Fascin

marker for Reed-Sternberg cells of Hodgkin disease

55K2

Non-Langerhans Cell Histiocytoses

Fibronectin

extracellular matrix glycoprotein

FN1, A0245, CIG

Cutaneous Mixed Tumor (Chondroid Syringoma)

FLI-1

Friend leukemia virus integration 1

EWSR2, GI146-222, SC356, FLK-1, FLT-1

Angiosarcoma; Epithelioid Hemangioendothelioma; Epithelioid Sarcoma; Kaposi Sarcoma; Kaposiform Hemangioendothelioma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

FOXP1

forkhead box transcription factor P1

JC12

Diffuse Large B-cell Lymphoma, Leg Type

FOXP3

forkhead box transcription factor P3

FoxP3

Adult T-cell Leukemia/Lymphoma

FVIIIRAg

factor VIII-related antigen

FVIIIRAG, F8/86, von Willebrand factor

Angiolymphoid Hyperplasia with Eosinophilia; Epithelioid Sarcoma; Extramedullary Hematopoiesis; Infantile Hemangioma; Lymphangioma and Superficial Lymphangioma; Papillary Intralymphatic Angioendothelioma (Dabska Tumor); Retiform Hemangioendothelioma; Spindle Cell Hemangioma

FXIIIA

factor XIIIA (fibrin stabilizing factor)

factor XIIIa

Acral Fibrokeratoma; Dermatofibroma and Fibrous Histiocytoma; Dermatofibrosarcoma Protuberans; Dermatomyofibroma; Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Histiocytoma; Juvenile and Adult-type Xanthogranuloma; Multinucleate Cell Angiohistiocytoma; Non-Langerhans Cell Histiocytoses; Pleomorphic Fibroma; Plexiform Fibrohistiocytic Tumor; Reticulohistiocytoma; Sclerotic Fibroma

GCDFP-15

gross cystic fluid protein 15

SABP, GPIP4, Gp17, 23A3, BRST-2, D6 (GROSS CYSTIC DISEASE FLUID PROTEIN)

Apocrine Carcinoma (Apocrine Adenocarcinoma); Apocrine Tubular Adenoma; Clear Cell Papulosis; Cutaneous Ciliated Cyst; Extramammary Paget Disease; Metastatic Tumors to the Skin; Primary Cutaneous Mucinous Carcinoma; Sebaceous Carcinoma; Syringocystadenoma Papilliferum; Toker Cell Hyperplasia

GFAP

glial fibrillary acidic protein

6F2, M761, GA-51, GFP-8A

Dermal Nerve Sheath Myxoma; Granular Cell Tumor; Nasal Glial Heterotopia; Neurofibroma; Neuromas; Perineurioma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Schwannoma (Neurilemmoma); Sinonasal Melanoma

Glucose transporter 1

GLUT1

Branchial Cleft Cyst

GLUT1

glucose transporter 1

Infantile Hemangioma; Kaposiform Hemangioendothelioma; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Perineurioma

GLUT1-cytoplasm

glucose transporter 1-cytoplasmic

GLUT1-CYT

Perineurioma

Glycophorin A

sialoglycoprotein of the human erythrocyte membrane

CD235a, JC159, GYPA, CD235a

Extramedullary Hematopoiesis

Granzyme B

neutral serine protease

GZM-B, 11F1, GR-B7

Subcutaneous Panniculitis-like T-cell Lymphoma

Gross cystic fluid protein 15

GCDPF-15, SABP, GPIP4, Gp17, 23A3, BRST-2, D6 (GROSS CYSTIC DISEASE FLUID PROTEIN)

Clear Cell Papulosis

GZM-B

neutral serine protease

Granzyme B, 11F1, GR-B7

Extranodal NK/T-cell Lymphoma, Nasal Type; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma

GZM-M

Serine protease contained by NK cells and some activated lymphocytes

Subcutaneous Panniculitis-like T-cell Lymphoma

H-caldesmon

High molecular weight caldesmon

H-CD

Angiomatoid Fibrous Histiocytoma; Childhood Melanoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Cutaneous Rhabdomyosarcoma; Fibromatosis; Glomus Tumors; Granular Cell Tumor; Leiomyoma (Pilar); Plexiform Fibrohistiocytic Tumor;

HCAD

H-caldesmon (high molecular weight caldesmon)

H-CD

Angioleiomyoma; Angiomatoid Fibrous Histiocytoma; Congenital Smooth Muscle Hamartoma; Glomus Tumors; PEComas

Hep-Par1

hepatocyte paraffin 1

OCH1E5.2.10, HEPPAR1

PEComas

HER2

v-erb-b2 erythroblastic leukemia viral gene protein, human epidermal growth factor receptor 2

c-erb-B2, HER2/neu, NEU, HER-2, NCL-CBE1, 10A7, 9G6.10, SP3, 4B5, P185, 9G6.20, A0485, C-ERBB-2, CB11, ERBB-2, 3B5, TAB250, HERCEPTEST, E2-4001, HER-2_NEU

Toker Cell Hyperplasia

HGAL

human germinal center-associated lymphoma

Primary Cutaneous Follicle Center Lymphoma

hHa1

stains specifically human hair keratin expressed starting from the upper part of the hair matrix, lower cortex, and hair cuticle

Pilomatrixoma and Pilomatrical Carcinoma

HHV8

human herpes virus 8

Kaposi sarcoma-associated herpes virus, KSHV, HUMAN HERPESVIRUS-8 LATENT NUCLEAR ANTIGEN-1, 13B10, LNA-1

Angiolipoma; Angiomatoid Fibrous Histiocytoma; Angiosarcoma; Capillary, Venous, and Cavernous Hemangiomas; Dermatofibroma and Fibrous Histiocytoma; Kaposi Sarcoma; Kaposiform Hemangioendothelioma; Multinucleate Cell Angiohistiocytoma; Progressive Lymphangioma; Pseudosarcomatous Fibroblastic Proliferations; Retiform Hemangioendothelioma; Spindle Cell Hemangioma; Venous Lake

HLA-DR

human leukocyte antigen DR

DK22, LN3, TAL.1B5, LK8D3

Blastic Plasmacytoid Dendritic Cell Neoplasm

HMB-45

antigen present in melanocytic tumors such as melanomas

LB39 AA, CMM1, CMM, DNS, FAMMM, Mart1, Melan-A, MLM, tyrosinase

Actinic Keratosis; Angiofibroma and Related Lesions; Angioleiomyoma; Angiolipoma; Atypical Fibroxanthoma; Atypical/Borderline and Malignant Spitz Tumors; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cellular Blue Nevi; Cellular Neurothekeoma; Childhood Melanoma; Conventional Blue Nevi; Dermal Nerve Sheath Myxoma; Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Histiocytoma; Epithelioid Sarcoma; Extramammary Paget Disease; Fibromatosis; Halo Nevi; Histiocytic Sarcoma; Leiomyosarcoma; Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Melanoma In Situ, NOS; Melanoma, Lentigo Maligna Type; Metastatic Skin Tumors; Neurofibroma; Neuromas; Oral Melanoma; Paragangliomalike Dermal Melanocytic Tumor; PEComas; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Pigmented Spindle Cell Nevus (Reed Nevus); Primary Dermal Melanoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Reticulohistiocytoma; Rhabdomyoma; Schwannoma (Neurilemmoma); Sinonasal Melanoma; Squamous Cell Carcinoma (and Variants); Superficial Malignant Peripheral Nerve Sheath Tumor; Other Unusual and Rare Variants of Melanoma

HPV

human papillomavirus

HPV-related Epidermal Cyst

HTLV-1

p40 tax antibody

Human T-cell Lymphotropic Virus, Human T-lymphotropic virus Type 1 (HTLV-I), Adult T-cell lymphoma virus type 1

Adult T-cell Leukemia/Lymphoma; Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Leukemia Cutis

Human germinal center-associated lymphoma

HGAL

Primary Cutaneous Follicle Center Lymphoma

IgA

immunoglobulin A

IGA

Primary Cutaneous Follicle Center Lymphoma

IgD

immunoglobulin D

IGD

Diffuse Large B-cell Lymphoma, Leg Type; Primary Cutaneous Follicle Center Lymphoma

IgF-2

insulin growth factor-like 2

W2-H1

Infantile Hemangioma

IgG

immunoglobulin G

IGG

Acantholytic and Acantholytic Dyskeratotic Acanthoma; Primary Cutaneous Follicle Center Lymphoma; Prurigo Nodularis; Pseudoepitheliomatous Hyperplasia

IgM

immunoglobulin M

IGM

Diffuse Large B-cell Lymphoma, Leg Type; Primary Cutaneous Follicle Center Lymphoma

IL-15

interleukin 15

Keloid and Cellular Scar

Immunoglobulin A

IgA, IGA

Subcutaneous Panniculitis-like T-cell Lymphoma

Inhibin-α

produced by ovarian granulosa cells; inhibits production or secretion of pituitary gonadotropins, a sensitive marker for majority of sex cord/stromal tumors

Granular Cell Tumor

INI1

member of SWI/SNF chromatin remodeling complex

BAF47/SNF5, SNF5

Angiosarcoma; Epithelioid Sarcoma; Fibromatosis; Myxoinflammatory Fibroblastic Sarcoma

IRF-4

interferon regulatory factor 4

MUM1P, clone MUM1, MUM1-IRF.4, MUM1, M17

Primary Cutaneous Follicle Center Lymphoma

Kappa

kappa light chain

KAPPA, κ light chain

Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

KBA62

Anti-melanoma associated antigen

KBA6.2

Childhood Melanoma; Desmoplastic Melanoma

Ki-67

Ki-67 (MIB-1); marker of cell proliferation

MMI, KI88, IVAK-2, MIB1

Actinic Cheilitis; Atypical Vascular Lesion; Atypical/Borderline and Malignant Spitz Tumors; Basal Cell Carcinoma; Diffuse Large B-cell Lymphoma, Leg Type; Extranodal NK/T-cell Lymphoma, Nasal Type; Granular Cell Tumor; Halo Nevi; Hidradenocarcinoma; Hidrocystoma (Apocrine and Eccrine); Intravascular Large B-cell Lymphoma; Kaposi Sarcoma; Large Cell Acanthoma; Lymphomatoid Papulosis; Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus); Melanoma In Situ, NOS; Melanoma In Situ, Superficial Spreading Type; Metastatic Skin Tumors; Microcystic Adnexal Carcinoma; Mycosis Fungoides (and Subtypes); Myxoinflammatory Fibroblastic Sarcoma; Nevoid Melanoma; Non-Langerhans Cell Histiocytoses; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Pigmented Spindle Cell Nevus (Reed Nevus); Poroma and Dermal Duct Tumor; Primary Dermal Melanoma; Sclerotic Fibroma; Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma; Systemic B-cell Lymphomas Involving the Skin; Trichoblastoma; Trichoepithelioma

Lambda

lambda light chain

λ light chain, LAMBDA

Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

Laminin

major protein in basal lamina

LAMININ-4C7, 4C12.8, LAM-89

Cutaneous Mixed Tumor (Chondroid Syringoma)

Langerin

CD207 molecule

CD207

Histiocytic Sarcoma; Non-Langerhans Cell Histiocytoses

LCA

leukocyte common antigen

PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26

Extramammary Paget Disease; Large Cell Acanthoma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

LEP

leptin

Lipoma

LEU-7

β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

CD57, NK1, HNK-1, TB01, B3GAT1

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

LMP1

Epstein-Barr virus latent membrane protein

EBV-LMP, CS 1-4

Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Systemic B-cell Lymphomas Involving the Skin

Lysozyme

1,4-beta N-acetylmuramidase C

Lyz, Lzm, Ec3.2.1.17

Dermatofibrosarcoma Protuberans; Histiocytic Sarcoma; Leukemia Cutis; Multicentric Reticulohistiocytosis; Multinucleate Cell Angiohistiocytoma; Plexiform Fibrohistiocytic Tumor; Reticulohistiocytoma

LYVE-1

lymph vessel endothelial hyaluronan receptor 1

Lymphangioma and Superficial Lymphangioma

MAC387

macrophage antibody

Multicentric Reticulohistiocytosis

Mammaglobin

Breast tissue-specific glycoprotein

304-1A5

Apocrine Carcinoma (Apocrine Adenocarcinoma); Metastatic Tumors to the Skin

Mart-1

mart-1 clone of Melan-A

Mucosal Melanoma (Genital); PEComas

MDM2

murine double minute oncogene (mdm2)

HDM2, IF2, 2A10, 1B10, SMP14, murine double minute 2

Atypical Lipomatous Tumor and Liposarcoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Hibernoma; PEComas; Spindle Cell and Pleomorphic Lipoma

Melan-A

melanoma antigen recognized by T cells 1 (MART-1); protein found on melanocytes; melanocyte differentiation antigen

M2-7C10, CK-MM

Angiofibroma and Related Lesions; Atypical/Borderline and Malignant Spitz Tumors; Desmoplastic Melanoma; Fibromatosis; Halo Nevi; Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Metastatic Skin Tumors; Sinonasal Melanoma; Squamomelanocytic Tumor

Melan-A103

clone of Melan-A

A103

Angioleiomyoma; Atypical Fibroxanthoma; Atypical/Borderline and Malignant Spitz Tumors; Cellular Neurothekeoma; Desmoplastic Melanoma; Halo Nevi; Metastatic Skin Tumors; Oral Melanoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sinonasal Melanoma; Squamomelanocytic Tumor

met

met proto-oncogene

8F11, C-28, C-MET

Cutaneous and Systemic Mastocytosis; Metastatic Tumors to the Skin

MIC2

cell surface glycoprotein for migration, T-cell adhesion

CD99, CD99-MEMB, MIC2, 12E7, HBA71, O13, P30/32MIC2, M3601

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

Micropthalmia transcription factor

MITF, 34CA5, D5, C5+D5

Sinonasal Melanoma

MITF

micropthalmia transcription factor

34CA5, D5, C5+D5

Atypical Fibroxanthoma; Cellular Neurothekeoma; Childhood Melanoma; Metastatic Skin Tumors; Oral Melanoma; PEComas; Plexiform Fibrohistiocytic Tumor; Sinonasal Melanoma; Other Unusual and Rare Variants of Melanoma

MLH1

mutL homolog 1

HMLH1, G168-15, G168-728, MMR family; HNPCC2, COCA2

Sebaceoma (Sebaceous Epithelioma); Sebaceous Adenoma; Sebaceous Carcinoma

MPO

myeloperoxidase

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous and Systemic Mastocytosis; Extramedullary Hematopoiesis; Histiocytic Sarcoma; Leukemia Cutis

MSA

actin, smooth muscle

actin-sm, ASM-1, CGA7, 1A4, HUC1-1

Adenoid Cystic Carcinoma; Atypical Fibroxanthoma; Childhood Melanoma; Dermatomyofibroma; Leiomyosarcoma; Sinonasal Melanoma

MSH2

mutS homolog 2

FE11

Sebaceoma (Sebaceous Epithelioma); Sebaceous Adenoma; Sebaceous Carcinoma

MSH6

mutS homolog 6

clone 44, GRBP.P1, DNA mismatch repair protein MSH6 antibody, G/T mismatch binding protein antibody, GTBP antibody, GTMBP antibody, HNPCC 5 antibody, HNPCC5 antibody, HSAP antibody, MSH 6 antibody, mutS (E. coli) homolog 6 antibody

Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma

MUC4

mucin 4, tracheobronchial

8G7

Low-Grade Fibromyxoid Sarcoma (Evans Tumor)

MUM1

Interferon regulatory factor 4

IRF-4, MUM1P, clone MUM1, MUM1-IRF.4, M17

Blastic Plasmacytoid Dendritic Cell Neoplasm; Diffuse Large B-cell Lymphoma, Leg Type; Leukemia Cutis; Lymphomatoid Papulosis; Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

MxA

Protein induced by alpha interferon protein

Blastic Plasmacytoid Dendritic Cell Neoplasm

myc

myelocytomatosis viral oncogene

C-MYC, c-myc, 9E10, 9E11, 1-262

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type

Myeloperoxidase

MPO

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous and Systemic Mastocytosis; Extramedullary Hematopoiesis; Histiocytic Sarcoma

MYOD1

myogenic differentiation 1

5.8A, 5.2F

Angiomatoid Fibrous Histiocytoma; Congenital Smooth Muscle Hamartoma; Cutaneous Rhabdomyosarcoma; Epithelioid Sarcoma; Pseudosarcomatous Fibroblastic Proliferations; Rhabdomyoma; Sinonasal Melanoma

Myogenin

myogenin

F5D, MYF3, MYF4, MYOGENIN, LO26

Angiomatoid Fibrous Histiocytoma; Angiosarcoma; Congenital Smooth Muscle Hamartoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Cutaneous Rhabdomyosarcoma; Epithelioid Sarcoma; Granular Cell Tumor; Hibernoma; Pseudosarcomatous Fibroblastic Proliferations; Rhabdomyoma; Sinonasal Melanoma; Superficial Malignant Peripheral Nerve Sheath Tumor

Myoglobin

iron and oxygen-building protein found in muscle tissue

MG-1

Botryoid Rhabdomyosarcoma; Gingival Granular Cell Tumor of the Newborn; Inflammatory Myofibroblastic Tumor; Rhabdomyoma; Rhabdomyosarcoma

Neurofilament protein

neurofilament H/M phosphorylated protein

NFP, TPNFP-1A3, SMI31, SMI33, NFP, SMI32, TA-51, 2F11

Neurofibroma; Neuromas; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

NFP

neurofilament H/M phosphorylated protein

TPNFP-1A3, SMI31, SMI33, NFP, SMI32, TA-51, 2F11

Neurofibroma; Neuromas; Perineurioma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

NGFR

nerve growth factor receptor

Granular Cell Tumor

NKI/C3

tetraspan intracellular granule protein

CD63, basophil activation test in allergy

Cellular Neurothekeoma Plexiform Fibrohistiocytic Tumor

NSE

neuron specific enolase

BSS/H14

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Mixed Tumor (Chondroid Syringoma); Granular Cell Tumor; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sinonasal Melanoma

Nuclear p53

p53 tumor suppressor gene protein

D07, 21N, BP53-12-1, AB6, CM1, PAB1801, DO1, BP53-11, PAP240, RSP53, MU195, P53

Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma

OCT2

octamer binding transcription factor 2

SC233

Lymphomatoid Granulomatosis

p15

cyclin-dependent kinase 4 inhibitor B

P15-INK4B

Primary Cutaneous Follicle Center Lymphoma

p16

cyclin-dependent kinase 4 inhibitor 2A

P16_INK4A, E6H4, sc1661, JC8, JZ11, P16, G175-405, F-12, DCS-50, 6H12, 16P07, 16P04

Atypical/Borderline and Malignant Spitz Tumors; Childhood Melanoma; Condyloma Acuminatum (Genital Wart); Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus); Melanoma In Situ, NOS; Melanoma In Situ, Superficial Spreading Type; Penile and Vulvar Intraepithelial Neoplasia; Pigmented Spindle Cell Nevus (Reed Nevus); Primary Cutaneous Follicle Center Lymphoma; Sinonasal Melanoma; Syringocystadenoma Papilliferum

p53

p53 tumor suppressor gene protein

Actinic Keratosis; Atypical Vascular Lesion; Basal Cell Carcinoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Granular Cell Tumor; Hidradenocarcinoma; Microcystic Adnexal Carcinoma; Penile and Vulvar Intraepithelial Neoplasia; Primary Dermal Melanoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma; Superficial Malignant Peripheral Nerve Sheath Tumor; Trichoblastoma; Trichoepithelioma

p63

tumor protein p63

H-137, 7JUL

Adenoid Cystic Carcinoma; Atypical Fibroxanthoma; Basal Cell Carcinoma; Childhood Melanoma; Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Sarcoma; Extramammary Paget Disease; Hidradenocarcinoma; Histiocytic Sarcoma; Leiomyosarcoma; Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Malignant Mixed Tumor; Median Raphe Cyst; Metastatic Skin Tumors; Metastatic Tumors to the Skin; Papillary Eccrine Adenoma; Porocarcinoma; Primary Cutaneous Mucinous Carcinoma; Proliferating Pilar (Trichilemmal) Cyst/Tumor; Sebaceous Carcinoma; Squamoid “Eccrine” Ductal Carcinoma; Squamous Cell Carcinoma (and Variants); Syringocystadenoma Papilliferum

pax-5

paired box gene 2

Z-RX2, PAX-2

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Plasmacytoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Histiocytic Sarcoma; Intravascular Large B-cell Lymphoma; Leukemia Cutis; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin; Systemic T-cell and NK-cell Lymphomas Involving the Skin

pax-8

paired box gene 8

Sebaceous Carcinoma

PCNA

proliferating cell nuclear antigen

19 A2, PC10

Large Cell Acanthoma; Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus)

PD-1

programmed cell death protein 1

EH12, NAT105, programmed death 1

Angioimmunoblastic T-cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma

Perforin

P1-8, PE-41-PU, 5B10

Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Lymphomatoid Papulosis; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma

PGP9.5

protein gene product 9.5

31A3,13C4

Granular Cell Tumor; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Plexiform Fibrohistiocytic Tumor

Podoplanin

transmembrane mucoprotein (38 kd) recognized by the D2-40 monoclonal antibody

D2-40, M2A

Angiomatoid Fibrous Histiocytoma; Angiosarcoma; Atypical Vascular Lesion; Cellular Neurothekeoma; Epithelioid Hemangioendothelioma; Kaposi Sarcoma; Kaposiform Hemangioendothelioma; Lymphangioma and Superficial Lymphangioma; Metastatic Tumors to the Skin; Progressive Lymphangioma; Rosai-Dorfman Disease; Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma

PR

progesterone receptor protein

PRP, 10A9, PGR-1A6, KD68, PGR-ICA, PRP-P, PRI, 1A6, 1AR, HPRA3, PGR-636, 636, PR88, NCL-PGR

Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Angiomyofibroblastoma; Apocrine Carcinoma (Apocrine Adenocarcinoma); Cutaneous Gamma-Delta T-cell Lymphoma; Metastatic Tumors to the Skin; Primary Cutaneous Mucinous Carcinoma

PRAD1

protein with important cell cycle regulatory functions

Cyclin-D1, bcl-1 (cyclin D1) A-12, AM29, DCS-6, SP4, 5D4, D1GM, P2D11F11, CCND1Cyl-1

Systemic B-cell Lymphomas Involving the Skin

Prostate specific antigen

PSA, PSA-M, PSA, ER-PR8, PSA-P, F5

Metastatic Tumors to the Skin

PROX1

critical regulator of lymphangiogenesis

Lymphangioma and Superficial Lymphangioma

PSA

prostate specific antigen

PSA-M, PSA, ER-PR8, PSA-P, F5

Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Metastatic Tumors to the Skin; Pilar Sheath Acanthoma

PTEN

phosphatase and tensin homolog

PN37

Fibrolipomatous Hamartoma of Nerve; Mycosis Fungoides (and Subtypes); Tricholemmoma

RCC

renal cell carcinoma antibody

66.4C2, PN-15, RCC MA

Hidradenoma; Metastatic Tumors to the Skin; Sebaceous Carcinoma

S100

low molecular weight protein normally present in cells derived from neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes

S-100, A6, 15E2E2, Z311, 4C4.9

Actinic Keratosis; Adenoid Cystic Carcinoma; Angiofibroma and Related Lesions; Angioleiomyoma; Angiomyofibroblastoma; Angiosarcoma; Apocrine Tubular Adenoma; Atypical Fibroxanthoma; Atypical Lipomatous Tumor and Liposarcoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cellular Neurothekeoma; Childhood Melanoma; Chondroid Lipoma; Collagenous Fibroma; Congenital Smooth Muscle Hamartoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma; Cutaneous Mixed Tumor (Chondroid Syringoma); Cutaneous Myxoma and Angiomyxoma; Cutaneous Rhabdomyosarcoma; Cylindroma; Dermal Nerve Sheath Myxoma; Dermatofibrosarcoma Protuberans; Dermatomyofibroma; Desmoplastic Melanoma; Digital Fibromatosis (Infantile Digital Fibromatosis); Distinctive Dermal Clear Cell Mesenchymal Tumor; Eccrine Carcinoma; Eccrine Hamartomas; Ectopic Meningioma; Epithelioid Hemangioendothelioma; Epithelioid Histiocytoma; Epithelioid Sarcoma; Extramammary Paget Disease; Fibromatosis; Fibrosarcoma; Glomus Tumors; Granular Cell Tumor; Halo Nevi; Hibernoma; Histiocytic Sarcoma; Juvenile and Adult-type Xanthogranuloma; Keloid and Cellular Scar; Langerhans Cell Histiocytosis; Leiomyosarcoma; Leukemia Cutis; Lipoma; Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Malignant Mixed Tumor; Melanoma In Situ, Superficial Spreading Type; Metastatic Skin Tumors; Mucosal Melanoma (Genital); Multicentric Reticulohistiocytosis; Myofibroma and Myofibromatosis; Myxofibrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nasal Glial Heterotopia; Neurofibroma; Neuromas; Non-Langerhans Cell Histiocytoses; Oral Melanoma; Other Unusual and Rare Variants of Melanoma; Papillary Eccrine Adenoma; Paraganglioma-like Dermal Melanocytic Tumor; PEComas; Perineurioma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Plexiform Fibrohistiocytic Tumor; Polyvinylpyrrolidone Storage Disease; Primary Dermal Melanoma; Primary Neuroendocrine (Merkel Cell) Carcinoma; Pseudosarcomatous Fibroblastic Proliferations; Reticulohistiocytoma; Rosai-Dorfman Disease; Schwannoma (Neurilemmoma); Sebaceous Carcinoma; Sinonasal Melanoma; Spindle Cell and Pleomorphic Lipoma; Spindle Cell Hemangioma; Spiradenoma; Squamomelanocytic Tumor; Squamous Cell Carcinoma (and Variants); Superficial Acral Fibromyxoma; Superficial Malignant Peripheral Nerve Sheath Tumor; Toker Cell Hyperplasia

S100-A6

S100 calcium binding protein A6

calcyclin, S-100A6, CACY-100

Plexiform Fibrohistiocytic Tumor

S100-pla

S100 placental

S100P, S0084

Angiosarcoma

S100P

S100 placental

S100-pla, S0084

Angiomatoid Fibrous Histiocytoma; Angiosarcoma; Atypical Lipomatous Tumor and Liposarcoma; Congenital Smooth Muscle Hamartoma; Glomus Tumors

SCC

squamous cell carcinoma-related antigen

F2H7C

Basal Cell Carcinoma; Branchial Cleft Cyst; Metastatic Tumors to the Skin; Sebaceous Carcinoma; Squamous Cell Carcinoma (and Variants)

SNF5

member of SWI/SNF chromatin remodeling complex

BAF47/SNF5, INI1

Angiosarcoma

SOX9

SRY (sex-determining region Y)-box 9 protein

CMD1, CMPD1

Basal Cell Carcinoma

SOX10

SRY (sex-determining region Y)-box 10 protein

Childhood Melanoma; Desmoplastic Melanoma

Stem cell factor

SCF

Cutaneous and Systemic Mastocytosis

Surface immunoglobulins

Sig

Primary Cutaneous Follicle Center Lymphoma

Synaptophysin

major synaptic vesicle protein p38 antibody

SVP38, SY38, SNP-88, SYP, SYPH, Sypl, Syn p38

Dermal Nerve Sheath Myxoma; Ectopic Meningioma; Extramammary Paget Disease; Leukemia Cutis; Metastatic Skin Tumors; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sinonasal Melanoma; Squamous Cell Carcinoma In Situ (Bowen Disease)

TAG72

tumor-associated glycoprotein-72

CC49, B72.3, BRST-3

Metastatic Tumors to the Skin

TARC

thymus and activation regulated chemokine

Leukemia Cutis

TCL1

trophoblast membrane protein 1

NDOG1

Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia Cutis

TCR

T-cell receptor antigen

T_Cell_AG_R, Beta-F1, 8A3, BF1

Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous Gamma-Delta T-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Intravascular Large B-cell Lymphoma; Mycosis Fungoides (and Subtypes); Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

TCR-β

Antibody directed toward the beta chain of the TCR-αβ heterodimer

Subcutaneous Panniculitis-like T-cell Lymphoma

TCR-βF1

specific for TCR beta chain constant region

Beta F1

Cutaneous Gamma-Delta T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma

TCR-δ-1

T-cell receptor delta chain 1

Cutaneous Gamma-Delta T-cell Lymphoma

TdT

terminal deoxynucleotidyl transferase

SEN28

Blastic Plasmacytoid Dendritic Cell Neoplasm; Leukemia Cutis

Tenascin

Extracellular matrix glycoprotein

DB7, TN2

Cutaneous Mixed Tumor (Chondroid Syringoma)

Thyroglobulin

dimetric protein specific to thyroid gland

DAK-TG6

Metastatic Tumors to the Skin

TIA

T-cell intracellular antigen 1

NS/1-AG4, 2G9, TIA-1

Cutaneous Gamma-Delta T-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Primary Cutaneous Anaplastic Large Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma

TIA-1

T-cell intracellular antigen 1

NS/1-AG4, 2G9, TIA

Adult T-cell Leukemia/Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Leukemia Cutis; Lymphomatoid Papulosis; Subcutaneous Panniculitis-like T-cell Lymphoma

TRAP

tartrate-resistant acid phosphatase

26E5, 9C5

Giant Cell Tumor of Tendon Sheath; Neurofibroma; Nevoid Melanoma

Tryptase

serine proteinase contained in mast cells

Cutaneous and Systemic Mastocytosis

TTF-1

transcription termination factor

8G7G3/1, SPT-24, SC-13040

Lymphoepithelioma-like Carcinoma of the Skin (LELCS); Metastatic Skin Tumors; Metastatic Tumors to the Skin; Primary Neuroendocrine (Merkel Cell) Carcinoma; Sebaceous Carcinoma

TTF-1 cytoplasmic

transcription termination factorcytoplasmic

SC-13040_CP, 8G7G3/1_CP, TTF-1 CYTOP

Metastatic Skin Tumors

Tyrosinase

catalyzes production of melanin

NCL-TYROS, T311

Actinic Keratosis; Atypical Fibroxanthoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Childhood Melanoma; Desmoplastic Melanoma; Distinctive Dermal Clear Cell Mesenchymal Tumor; Extramammary Paget Disease; Halo Nevi; Histiocytic Sarcoma; Melanoma In Situ, NOS; Oral Melanoma; PEComas; Sinonasal Melanoma; Superficial Malignant Peripheral Nerve Sheath Tumor; Other Unusual and Rare Variants of Melanoma

Uroplakin-3

AU 1, Uroplakin III

Extramammary Paget Disease

VEGF

vascular endothelial growth factor

JH121, 26503.11, VPF, VPF/VEGF, VEGFA, VEGF-C, RP 077, VEGFR-1, RP 076, VEGFR-2, 9D9, VEGFR-3, FLT-4

Infantile Hemangioma

VEGFR-3

vascular endothelial growth factor

JH121, 26503.11, VPF, VPF/VEGF, VEGFA, VEGF-C, RP 077, VEGFR-1, RP 076, VEGFR-2, 9D9, VEGF, FLT-4

Lymphangioma and Superficial Lymphangioma; Papillary Intralymphatic Angioendothelioma (Dabska Tumor); Retiform Hemangioendothelioma

Vimentin

major subunit protein of the intermediate filaments of mesenchymal cells

43BE8, 3B4, V10, V9, VIM-3B4, VIM

Atypical Fibroxanthoma; Cutaneous Mixed Tumor (Chondroid Syringoma); Dermatofibroma and Fibrous Histiocytoma; Distinctive Dermal Clear Cell Mesenchymal Tumor; Epithelioid Sarcoma; Fibrosarcoma; Fibrous Hamartoma of Infancy; Malignant Mixed Tumor; Multinucleate Cell Angiohistiocytoma; Myofibroma and Myofibromatosis; Neurofibroma; Oral Melanoma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Pleomorphic Fibroma; Sclerotic Fibroma; Sinonasal Melanoma; Squamous Cell Carcinoma (and Variants)

WT1

Wilms tumor gene-1

6F-H2, C-19

Metastatic Tumors to the Skin; Vascular Hamartomas; Verrucous Hemangioma