Angiomyofibroblastoma
Marisa Nucci, MD
Cyril Fisher, MD, DSc, FRCPath
Key Facts
Terminology
Benign stromal tumor composed of numerous capillaries and myofibroblasts
Clinical Issues
Often thought to represent a cyst
Local excision
No recurrent potential
Microscopic Pathology
Well demarcated
Numerous thin-walled capillaries
Alternating zones of cellularity
Variably edematous to collagenous matrix
Plump, ovoid (plasmacytoid) to spindle-shaped cells
Cells cluster around capillaries
Ancillary Tests
Typically desmin positive
 Angiomyofibroblastoma is characterized by numerous capillary-sized vessels  , alternating zones of cellularity and more fibrous areas  , without necrosis. |
 The stromal cells tend to cluster around the prominent yet delicate vascular component. The intervening tissue is sparsely cellular and contains slender collagen fibrils. The cells lack nuclear atypia. |
TERMINOLOGY
Abbreviations
Angiomyofibroblastoma (AMF)
Definitions
Benign stromal tumor composed of numerous capillaries and myofibroblasts
ETIOLOGY/PATHOGENESIS
Cell of Origin
Subepithelial mesenchyme of distal female genital tract
CLINICAL ISSUES
