Angiomyofibroblastoma
Marisa Nucci, MD
Cyril Fisher, MD, DSc, FRCPath
Key Facts
Terminology
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Benign stromal tumor composed of numerous capillaries and myofibroblasts
Clinical Issues
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Often thought to represent a cyst
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Local excision
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No recurrent potential
Microscopic Pathology
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Well demarcated
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Numerous thin-walled capillaries
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Alternating zones of cellularity
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Variably edematous to collagenous matrix
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Plump, ovoid (plasmacytoid) to spindle-shaped cells
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Cells cluster around capillaries
Ancillary Tests
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Typically desmin positive
Angiomyofibroblastoma is characterized by numerous capillary-sized vessels  , alternating zones of cellularity and more fibrous areas  , without necrosis. |
The stromal cells tend to cluster around the prominent yet delicate vascular component. The intervening tissue is sparsely cellular and contains slender collagen fibrils. The cells lack nuclear atypia. |
TERMINOLOGY
Abbreviations
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Angiomyofibroblastoma (AMF)
Definitions
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Benign stromal tumor composed of numerous capillaries and myofibroblasts
ETIOLOGY/PATHOGENESIS
Cell of Origin
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Subepithelial mesenchyme of distal female genital tract
CLINICAL ISSUES
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