Angiolymphoid Hyperplasia With Eosinophilia

 Endothelial cells may have cytoplasmic vacuolization

image May have solid appearance

• Many eosinophils, lymphocytes, and mast cells, although eosinophil number can vary greatly

Top Differential Diagnoses

• Papillary endothelial hyperplasia

• Kimura disease

• Angiosarcoma

• Metastatic papillary thyroid carcinoma

Subepithelial Vascular Proliferation
Hematoxylin and eosin shows an intact surface epithelium with a richly vascularized stroma containing lymphoid elements. Eosinophils are present, imparting a bright red appearance at this low magnification.

Vascular Proliferation With Eosinophils
There are sheets of eosinophils in the background stroma. The vascular spaces are lined by endothelial cells that are enlarged and prominent. There is no atypia and no anastomosing.

High Endothelial Cells
The endothelial cells image are enlarged and partly occlude the lumen. Eosinophils image are noted in the background. Sometimes the eosinophils are inconspicuous.

Endothelial Hyperplasia
Hematoxylin and eosin shows endothelial hyperplasia with a thickened vessel wall and increased inflammatory cells, including eosinophils, in the surrounding tissue. Note the extravasated erythrocytes.



• Angiolymphoid hyperplasia with eosinophilia


• Epithelioid hemangioma

• Nodular, angioblastic hyperplasia with eosinophilia and lymphofolliculosis


• Benign vascular tumor with well-formed, immature blood vessels, most of which are lined by plump, epithelioid (histiocytoid) endothelial cells with prominent inflammatory component, especially eosinophils



• History of trauma; larger vessels show damage with prominent inflammatory component


• May represent benign neoplasm, with evidence of clonal T-cell population in some cases



• Age
image Wide range; mean: 3rd to 5th decades

• Sex
image F > M

• Ethnicity
image Not increased in Asian patients (i.e., not Kimura disease)

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Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Angiolymphoid Hyperplasia With Eosinophilia

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