Keratinocytes

Jul 23, 2022 by in GENERAL & FAMILY MEDICINE Comments Off on Keratinocytes

Key points • Epidermis is the outermost layer of skin surface that forms the first line of defense against invaders from the environment. Keratinocyte is the epidermis’s principle cell type…

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Cellular Factors

Jul 23, 2022 by in GENERAL & FAMILY MEDICINE Comments Off on Cellular Factors

Key points • Atopic dermatitis (AD) is a complex disease with various types of leukocytes involved in its pathology. • Multiple subsets of CD4 + helper T cells, which are…

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Epigenetics

Jul 23, 2022 by in GENERAL & FAMILY MEDICINE Comments Off on Epigenetics

Key points • There are three major types of epigenetic modifications: DNA methylation, microRNAs, and posttranslational histone modifications. • DNA methylation and microRNAs alter the expression of atopic dermatitis-associated genes…

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Humoral Factors

Jul 23, 2022 by in GENERAL & FAMILY MEDICINE Comments Off on Humoral Factors

Key points • Allergen-specific B cells are differentiated into plasma cells producing immunoglobulin E (IgE) antibodies. Through binding to the receptors (FcεRI and FcεRII), IgE induces cytokine and chemokine production…

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Nutrition

Jul 23, 2022 by in GENERAL & FAMILY MEDICINE Comments Off on Nutrition

Key points • Maternal supplementation of omega-3 polyunsaturated fatty acids may reduce risk of atopic dermatitis (AD). • Fish intake during early childhood may decrease the risk of developing AD….

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