Role of the Mrgpr Receptor Family in Itch
Fig. 1 Venn diagram summarizing the expression of Mrgprs in DRG neurons. The small- to medium-diameter neurons represent the major primary sensory neuron population in the DRG and can be…
Topical and Systemic Therapies for Itch
Agent Indications Major adverse effects Coolants: menthol, camphor, phenol Most pruritic conditions Skin irritation Capsaicin 0.025–0.1 % • Neuropathic itch • Prurigo nodularis • Aquagenic pruritus • Uremic pruritus Initial burning…
Antagonists and Itch
Cell/structure Effects of SP/NK1R Potential translational importance References Epidermal dendritic cells Increased migration to skin-draining lymph nodes; inhibition of IL-10 synthesis and secretion NK1R agonists: potential adjuvant for enhancing the…
of Cytokines and Chemokines in Itch
Fig. 1 IL-31 is predominantly produced by TH2 cells in humans. Factors influencing this release include exogenous triggers such as staphylococcal enterotoxin B (SEB), house dust mites (HDM) and endogenous…
Epidemiology and Quality of Life
Author N Population Age % Female 12-month cumulative incidence Point prevalence 12-month prevalence Lifetime prevalence Rea (1976) 1,979 Residents of North Lambeth with skin diseases 15–74 49.3 % N/A 8.2 % N/A…
Background of Itch
1922 Von Frey suggests that itch is transmitted by the same network of fibres as pain and may be induced by mechanical, thermal, chemical and thermal stimuli 1939 Bickford proposes…
Mechanisms of Angina Pectoris
Figure 1.1 Scheme of cardiac pain pathway. Pain originated from the heart is transmitted to a second neuron in the dorsal horn of the spinal cord, which carries out the…
Nicorandil
Figure 6.1 Chemical structure of nicorandil Mechanism of Action Anti-Angina Actions Nicorandil has two distinct anti-angina mechanisms (Fig. 6.2) [1–3]. The nitrate component acts mainly on systemic venous (capacitance) vessels…
Medical Therapy Versus Revascularization in the Management of Stable Angina Pectoris
Figure 11.1 Pooled risk ratios for various end points from six randomised controlled trials comparing percutaneous transluminal coronary angioplasty (PCTA) with medical treatment in patients with non-acute coronary heart disease;…
Trimetazidine
Study Follow up duration Type of intervention % Patients with angina BARI [1] 1 year CABG, PCI 10 % CABG, 30 % PCI COURAGE [2] 5 years PCI, MT 26…
