Graft-vs.-Host Glomerulopathies Anthony Chang, MD Key Facts Terminology Graft-vs.-host disease (GVHD) glomerulopathy Glomerular injury in setting of hematopoietic cell transplantation and GVHD Clinical Issues Proteinuria, nephrotic range Microscopic Pathology 3…
Drug-induced Minimal Change Disease Anthony Chang, MD Key Facts Etiology/Pathogenesis Common offending agents Nonsteroidal anti-inflammatory drugs (NSAIDs) Cyclooxygenase 2 inhibitors Pamidronate Interferon-α and interferon-β Rifampin Clinical Issues Nephrotic syndrome Treatment…
Lymph Nodes, Axillary: Diagnosis Afferent lymphatics enter the node in a central plane. Bisecting the node in this plane is most likely to reveal metastasis. Macrometastases should be detectable regardless…
Liver: Evaluation of Allograft Prior to Transplantation Each component of the liver parenchyma is evaluated systematically: Portal tracts with duct , artery and vein, portal-lobular interface , hepatocytes , and…
Cerebral Hemispheres: Diagnosis Glioblastoma is the most common and most aggressive brain tumor, illustrated here as a large mass with a hemorrhagic and necrotic center and extending across the corpus…
Lung: Nonneoplastic Diffuse Disease: Diagnosis Tissue procured to diagnose nonneoplastic lung disease is generally taken as a wedge-shaped fragment from the periphery of 1 or multiple lobes. Staples in the…
Bone Lesion/Tumor: Diagnosis and Margins The morphology of metastatic carcinoma varies widely depending on the type of primary tumor and degree of differentiation. This metastatic adenocarcinoma displays well-formed glandular elements…
Esophagus: Diagnosis and Margins The most common esophageal tumor is adenocarcinoma arising near the gastroesophageal (GE) junction. The proximal margin is is covered by squamous mucosa and the distal margin…
Lung: Margins The bronchial margin may be identified as 1 or 2 small firm-walled tube(s) . At times, the surgeon may mark the margin with a stitch. The site is…
Fallopian Tube: Diagnosis An ectopic pregnancy can be a medical emergency and is identified by immature placental villi and implantation site within a fallopian tube. Fimbriae underlie the implantation site….
