Peripheral T-cell Lymphoma, Not Otherwise Specified James M. You, MD, PhD Key Facts Clinical Issues PTCL represents approximately 6.0% of all non-Hodgkin lymphomas Mainly arises in middle-aged adults; rare in…
Primary Effusion Lymphoma (PEL) and Solid Variant of PEL Francisco Vega, MD, PhD Key Facts Etiology/Pathogenesis PEL arises from HHV8-infected B cells frequently coinfected by EBV Associated with HIV infection…
ALK+ Anaplastic Large Cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology CD30(+) lymphoma of T- or null cell lineage having chromosomal abnormalities involving 2p23 (ALK locus) Clinical Issues Children…
Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type Sa A. Wang, MD Key Facts Terminology Primary cutaneous DLBCL composed exclusively of large transformed cells Clinical Issues 20% of primary cutaneous…
B-cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-cell Lymphoma and Burkitt Lymphoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Terminology Aggressive B-cell lymphoma with morphological and genetic features…
Lymphadenopathy Associated with Joint Prostheses Roberto N. Miranda, MD Key Facts Terminology Lymphadenopathy caused by abraded metal debris and cementing substances drained from sites of joint prostheses Etiology/Pathogenesis Hip and…
Diffuse Large B-cell Lymphoma, NOS, Immunoblastic Francisco Vega, MD, PhD Key Facts Terminology Diffuse proliferation of large neoplastic B cells with immunoblastic cytologic features Immunoblasts must be > 90% of…
Richter Syndrome Sergej Konoplev, MD, PhD Key Facts Terminology Aggressive lymphoma arising in patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) Subtypes Common: Diffuse large B-cell lymphoma Uncommon: Classical Hodgkin…
ALK− Anaplastic Large Cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Lymphoma histologically resembling spectrum of ALK(+) ALCL, with strong and uniform expression of CD30, but lacking ALK expression…
Mixed Cellularity Hodgkin Lymphoma C. Cameron Yin, MD, PhD Key Facts Terminology Subtype of classical Hodgkin lymphoma (CHL) with diffuse or interfollicular pattern, without nodular fibrosis Etiology/Pathogenesis Epstein-Barr virus (EBV)…
