Primary Mediastinal (Thymic) Large B-cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Diffuse large B-cell lymphoma (DLBCL) arising in mediastinum of putative thymic B-cell origin Clinical Issues Most frequent…
Angioimmunoblastic T-cell Lymphoma Sa A. Wang, MD Key Facts Terminology Peripheral T-cell lymphoma derived from CD4(+) follicular helper T cells characterized by Lymphadenopathy, systemic disease, and, usually, immunodysregulation and immunodeficiency…
Lymphoplasmacytic Lymphoma and Waldenstrom Macroglobulinemia Pei Lin, MD Key Facts Terminology LPL is a neoplasm of small B lymphocytes ± plasmacytoid features and plasma cells that does not meet criteria…
Interdigitating Dendritic Cell Sarcoma Wesley O. Greaves, MD L. Jeffrey Medeiros, MD Key Facts Clinical Issues Wide age range Single lymph nodes most commonly involved Cervical, axillary, or inguinal groups…
T-cell Prolymphocytic Leukemia Involving Lymph Node and Other Tissues Tariq Muzzafar, MBBS L. Jeffrey Medeiros, MD Key Facts Terminology T-PLL is aggressive disease characterized by Numerous small/medium-sized T prolymphocytes Involvement…
Primary Diffuse Large B-cell Lymphoma of the CNS Tariq Muzzafar, MBBS Key Facts Clinical Issues Neuropsychiatric signs and symptoms Raised intracranial pressure Intraocular involvement: blurred vision and floaters Image Findings…
Angiomyomatous Hamartoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Terminology Benign smooth muscle proliferation that begins in hilum and extends into medulla and cortex of lymph node Involves inguinal lymph…
Extranodal NK-/T-cell Lymphoma, Nasal Type L. Jeffrey Medeiros, MD Key Facts Etiology/Pathogenesis EBV is constant finding, present in clonal episomal form, and is likely involved in pathogenesis Clinical Issues Nasal…
Plasmacytoma Pei Lin, MD Key Facts Terminology Plasmacytoma is a neoplasm composed of monoclonal plasma cells that involves tissues No evidence of bone marrow involvement No clinical or laboratory evidence…
Overview of Lymphoproliferative Disorders Associated with Primary Immune Deficiency Disorders Keyur Patel, MD, PhD Chronic granulomatous inflammation involving lymph node in a patient with common variable immunodeficiency (CVID). B-cell lymphoma…
