Waldenstrom Protein
Scott R. Owens, MD
Key Facts
Etiology/Pathogenesis
Often associated with lymphoplasmacytic lymphoma (LPL)
Clinical Issues
Diarrhea and malabsorption may lead to intestinal biopsy
Microscopic Pathology
Dilated mucosal lymphatics containing PAS(+), diastase-resistant eosinophilic material
Ancillary Tests
IgM positive, light-chain restricted protein
Diagnostic Checklist
Examine biopsy carefully for opportunistic infections such as giardiasis
 Hematoxylin & eosin shows duodenal mucosa in a case of Waldenström macroglobulinemia. Lymphatic channels are dilated and filled with eosinophilic material  . |
 Hematoxylin & eosin shows dilated lymphatic channels filled with Waldenström protein  . |
TERMINOLOGY
Abbreviations
Waldenström macroglobulinemia (WM)
Synonyms
Waldenström syndrome
Definitions
Incurable lymphoproliferative disorder
Characterized by production of monoclonal IgM pentamers (“Waldenström protein”) and associated with plasma hyperviscosity
ETIOLOGY/PATHOGENESIS
Origin
Often associated with lymphoplasmacytic lymphoma (LPL)
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