Villous Adenoma
Jesse K. McKenney, MD
Key Facts
Terminology
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Benign glandular neoplasm arising from urothelium
Clinical Issues
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Presenting symptoms
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Hematuria and irritative bladder symptoms
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Rarely, mucosuria can be seen
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Therapy: Complete transurethral resection
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Excellent prognosis for villous adenoma with no invasive component and complete resection
Microscopic Pathology
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Villoglandular architecture
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Fibrovascular cores lined by pseudostratified columnar epithelium
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Invasive adenocarcinoma of enteric type may arise from villous adenoma
Diagnostic Checklist
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All tissue should be submitted for histologic evaluation to exclude invasive component
Villous adenoma of the urinary bladder has an identical morphology to its more common colorectal counterpart with variable papillary architecture and obvious intracellular mucin. |
On high-power examination, villous adenoma is characterized by pseudostratified columnar epithelium showing nuclear crowding and hyperchromasia. |
TERMINOLOGY
Definitions
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Benign glandular neoplasm of urinary bladder
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Histologically identical to colorectal adenomas
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CLINICAL ISSUES
Epidemiology
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Incidence
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Rare primary bladder neoplasm
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Age
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Wide age range
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Mean: 65 years
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Gender
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Male predominance
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Site
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Common sites include bladder dome and trigone
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May also occur in urachus
Presentation
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