Undifferentiated Carcinoma

Undifferentiated Carcinoma

Mari Mino-Kenudson, MD

This gross photograph of an undifferentiated carcinoma with osteoclast-like giant cells has a soft, fleshy cut surface with prominent hemorrhage image and necrosis image.

This undifferentiated carcinoma has a prominent sarcomatoid component featuring plump spindle cells in a fascicular pattern.



  • Pleomorphic carcinoma, pleomorphic large cell carcinoma, pleomorphic giant cell carcinoma

  • Undifferentiated carcinoma with osteoclast-like giant cells

    • Giant cell tumor of pancreas

    • Osteoclast-like giant cell tumor of pancreas


  • Malignant epithelial neoplasm with significant component showing no definite differentiation

    • Wide range of morphologic findings ranging from pleomorphic epithelioid cells to multinucleated giant cells to spindle cells

    • Multiple patterns often present within same tumor

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Undifferentiated Carcinoma
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