The process of forming the Commonwealth of Independent States (CIS) gave rise to a unique experience of dynamic legislative, administrative and informational development in the sphere of ethical regulation in biomedicine. This new concept of multilateral cooperation united 11 regional countries (The Azerbaijan Republic, Republic of Armenia, Republic of Belarus, Georgia , Republic of Kazakhstan , Kyrgyz Republic, Republic of Moldova, Russian Federation, Republic of Tajikistan , Republic of Uzbekistan and Ukraine ). As it was recognized that consensus in bioethics discussions could not be reached without first understanding and respecting political, economic, socio-cultural, historical, and religious differences, a detailed review of these aspects was carried out in a study supported by the UNESCO Moscow Office and the UNESCO Headquarters in the CIS countries. The study showed that “bioethics initiatives and consolidating activities in law-making, education, creation of the system for the ethical review and international cooperation have become a priority” (Kubar et al. 2007). The information obtained in this study was important for the dissemination, promotion, elaboration and application of ethical principles of the UNESCO Declarations as well as for bioethics programs, such as: Assisting Bioethics Committees , Ethics Education Program s and Global Ethics Observatory in the CEE countries (UNESCO Bioethics Programs 2013). It should be noted that in the successful realization of these goals, the role of UNESCO regional offices was very important. Following the creation of the UNESCO Assisting Bioethics Committees program, National Committees on Bioethics were established in all cluster countries of the UNESCO Moscow office, including: Azerbaijan, Armenia, Belorussia, Moldova and Russian Federation and in many other CEE countries. Special attention was focused on the networking and capacity building of these Committees to foster the exchange of information, support decision-making, develop tools for standard setting, and strengthen coordination among experts and institutions in the region (Volik 2010; Petrov and Yudin 2010). The concept of an Ethics Education Programme was inspired by the general historical goal of achieving ethical practice in the sphere of healthcare, based on universal ethical values. In fact the achievement of this goal depended upon the establishment of international cooperation for the implementation of the Ethics Education Program as a measure for promoting UNESCO Universal Declaration s. As a first step for implementing the Ethics Education Program in the region, based on the experience of bioethics education in Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyz Republic, Moldova, Russian Federation, Tajikistan, Uzbekistan and Ukraine, an analytical review of the current state of bioethics education in these countries was conducted (Kubar et al. 2010; Kubar 2013). A great contribution has also been made by the UNESCO Ethics Teacher Training Courses, in which students from more than 10 countries in the region and regional experts on bioethics took part. The positive results of such activity include the contributions of the Polish Bioethics Society and the Ukraine Bioethics Association at the national level, and the sub-regional Association for Education in Bioethics in the Commonwealth of Independent States (CIS) at the international level. Following Ethics Teacher Training Courses, educational bioethics programs at the regional level were organised to increase capacities in the area of ethics education and to improve all activities in the fields of bioethics and human rights. It should be noted that the UNESCO’s Ethics Education Program was translated into many national languages and pilot testing was conducted in local Universities. Accordingly, bioethics became a mandatory subject for students in biological and medical schools and there are courses at the Master’s level in countries such as Georgia, Poland and Russia. Activities with a special focus to promote ethical principles and to raise public awareness about bioethical issues as well as introduce bioethics into the agenda of the mass media for journalists were carried out by the UNESCO Moscow office in the long term project entitled “Bioethics and Media” (Tishenko and Yudin 2008). The importance of bioethics education has been emphasized by the establishment of the Units of the International Network of the UNESCO Chair in Bioethics in 10 regional countries: Albania, Armenia, Azerbaijan, Bulgaria, Croatia , Czech Republic, Macedonia, Russia, Serbia and Ukraine. This activity was supported by regional political bodies to facilitate the global process of bioethics capacity building and to facilitate bioethics-related legislation. The participation of the CEE region in the Global Ethics Observatory, in all its six databases provides a platform for experts’ collaborations and exchange of information at the regional and global levels. The need for bioethical guidelines is growing world-wide and has been addressed by several international bodies. In Europe one should mention the contributions of at least two organizations in this regard: the Bioethics Committee of the Council of Europe (DH-BIO) and the European Group on Ethics in Science and New Technologies (EGE). However, as the work of these bodies partly overlapped with that of UNESCO, some small countries like Slovenia mainly took part in the regional rather than global activities. In terms of the IBC’s impact on bioethics development in this region, special attention should be paid to the influence of UNESCO Declarations in the capacity building of human resources in bioethics. Another important development is the impact of the Universal Declaration on the Human Genome and Human Right s (UNESCO 1997) and the International Declaration of Human Genetic Data (UNESCO 2003) on regional legislation by the Recommendation of Inter-Parliamentary Assembly of the CIS “Ethical and Legal Regulation in Genetic Research in the CIS States”, and on national legislation in many regional countries (Kubar 2010; Petrov and Yudin 2010). The impact of the Universal Declaration on Bioethics and Human Right s (UNESCO 2005), which introduces ethical principles on important topics such as the protection of vulnerable populations, non-discrimination and non-stigmatisation on the development of bioethics discourse in this region, is noticeable. It should be noted that the UNESCO Declarations have been translated into all regional languages and are available on the UNESCO related websites and other media resources. These documents have become part of the professional and public educational programs in bioethics.