Introduction
Introduction For the hematopathologist involved in scientific research, lymphomas and leukemias present the most challenging field of medical investigation, one in which immunity and neoplasia interface and in which new…
Nevus Cell Inclusions in Lymph Nodes
Nevus Cell Inclusions in Lymph Nodes Definition Aggregates of nevus cells in the lymph node hilus, capsule, or trabeculae. Pathogenesis Aggregates of nevus cells within peripheral lymph nodes, first described…
Epithelial Cell Inclusions in Lymph Nodes
Epithelial Cell Inclusions in Lymph Nodes Definition Clusters of benign, well-differentiated epithelial cells in lymph nodes. Pathogenesis The presence of epithelial cells in lymph nodes is usually the result of…
Gold Lymphadenopathy
Gold Lymphadenopathy Definition Lymphadenopathy caused by intramuscular injections of gold and subsequent deposit in lymph nodes. Pathogenesis In chrysotherapy for rheumatoid arthritis, gold sodium thiomalate is injected intramuscularly over long…
Lymphadenopathy of Metal Debris Associated with Joint Prostheses
Lymphadenopathy of Metal Debris Associated with Joint Prostheses Definition Lymphadenopathy caused by abraded metal debris drained from sites of joint prostheses. Pathogenesis The use of metal prostheses to replace large…
Silicone Lymphadenopathy
Silicone Lymphadenopathy Definition Lymphadenopathy of regional lymph nodes caused by the presence of silicone carried from tributary organs. Pathogenesis Silicone consists of polymers of dimethylsiloxane. When repeating units are polymerized,…
Lipid Lymphadenopathy
Lipid Lymphadenopathy Definition Lymphadenopathy with foreign-body reaction to lipids of endogenous or exogenous origins. Pathogenesis Foreign-body reactions to lipids, in the form of lipogranulomas or lipogranulomatosis, may involve lymph nodes…
Proteinaceous Lymphadenopathy
Proteinaceous Lymphadenopathy Definition Enlarged lymph node with partial or total replacement of normal architecture by deposits of acellular amorphous material with the characteristic features of amyloid or of other proteinaceous…
Lymph Node Infarction
Lymph Node Infarction Definition Massive necrosis of coagulative type involving most of the nodal parenchyma and sparing only a narrow subcapsular rim. Pathogenesis Because of their abundant vascularity and well-developed…
Vascular Transformation of Sinuses
Vascular Transformation of Sinuses Definition Benign vascular proliferation of lymph nodes with characteristic sinus distribution. Pathogenesis Vascular transformation of sinuses (VTS) is a rare condition in which the vasoproliferative process…
