Spitz (Spindle and Epithelioid Cell) Nevi



Spitz (Spindle and Epithelioid Cell) Nevi


Jessica M. Comstock, MD

David Cassarino, MD, PhD










A pink papule, typical of a Spitz nevus, is shown on the face of a child. (Courtesy R. J. Antaya, MD.)






High-power examination of a Spitz nevus shows small nests of epithelioid to spindled melanocytes with overlying artifactual clefting image and an eosinophilic Kamino body image.


TERMINOLOGY


Synonyms



  • Spindle and epithelioid cell nevus


  • Spindle cell nevus


  • Epithelioid cell nevus


  • Nevus of large spindle &/or epithelioid cells


  • Benign juvenile melanoma (outdated term)


CLINICAL ISSUES


Site



  • Extremities, especially thigh


  • Trunk


  • Head and neck


Presentation



  • Most common in children and young adults



    • 0.5-1% of all nevi in children and adolescents


    • May occur at all ages


  • Solitary



    • Can be clustered or disseminated


Treatment



  • Complete conservative excision


Prognosis



  • Benign


  • Low recurrence rate, even after incomplete excision


MACROSCOPIC FEATURES


General Features



  • Dome-shaped dermal nodule


  • Pink or flesh-colored


  • Often misdiagnosed clinically as hemangioma or pyogenic granuloma


Size



  • Usually < 1 cm


MICROSCOPIC PATHOLOGY


Histologic Features

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Spitz (Spindle and Epithelioid Cell) Nevi
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