Solitary Rectal Ulcer Syndrome/Mucosal Prolapse

Solitary Rectal Ulcer Syndrome/Mucosal Prolapse

Julianne K. Purdy, MD

Hematoxylin & eosin shows polypoid ulcerated rectal mucosa with underlying fibromuscular proliferation in the lamina propria and serrated, branching, haphazardly arranged crypts image.

Hematoxylin & eosin shows hypertrophied, disorganized smooth muscle of the muscularis mucosa image, extending up into the lamina propria between crypts image.



  • Solitary rectal ulcer syndrome (SRUS)

    • Chronic benign defecation disorder with histologic features of mucosal prolapse


Contraction of Sphincter during Defecation

  • Excessive straining → compression of rectal wall, prolapse

  • Venous congestion, traction on submucosal vessels → poor blood flow → ischemia, ulceration

Direct Trauma

Jul 6, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Solitary Rectal Ulcer Syndrome/Mucosal Prolapse
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