Immunohistochemistry of Selected Spindle Cell Soft Tissue Tumors

Tumor

CD34

CK

SMA

S100

Desmin

Other Diagnostic Markers

Angiosarcoma

+

±

–

–

–

CD31, FLI-1, FVIIIRAg

Dermatofibrosarcoma

+

–

–

+ (Bednar)

–

Follicular dendritic cell sarcoma

–

–

–

+

–

CD21, CD23, CD35, fascin, D2-40

Gastrointestinal stromal tumor

+

–

+

–

±

CD117, DOG1, H-caldesmon

Inflammatory myofibroblastic tumor

–

±

+

–

±

ALK (50%)

Kaposi sarcoma

+

–

–

–

–

CD31, HHV8

Leiomyosarcoma

–

±

±

–

+

H-caldesmon, SMM

Myofibrosarcoma

–

–

+

–

±

Calponin, H-caldesmon (-)

Malignant peripheral nerve sheath tumor

±

±

–

±

+ (Triton)

Solitary fibrous tumor

+

–

–

–

–

Bcl-2, CD99, CD56

Spindle cell carcinoma

–

+

+

–

–

EMA, CK5/6, CK34βE12

Synovial sarcoma

–

+

–

±

–

EMA, TLE1, CD99, CD56

± = Positive in some cases.

Immunohistochemistry of Selected Epithelioid Cell Soft Tissue Tumors

Antibody

Epithelioid Sarcoma

Epithelioid MPNST

Epithelioid Angiosarcoma

Anaplastic Large Cell Lymphoma

Carcinoma

Melanoma

CK-PAN

+

–

+

–^*

+

–^*

EMA

+

–^*

–^*

+

+

–

S100

–

+

–

–

±

+

CD34

±

–

±

–

–

–

CD31

–

–

+

–

–

–

Desmin

–

–

–

–

–

–^*

SMA

+

–

–

–

–

–

INI1

–

±

+

+

+

+

p63

–

–

–

–

+

–

CD30

–^*

–

+

–

–

CD45

–

–

–

+

–

–

^* * Rarely positive. MPNST = malignant peripheral nerve sheath tumor.