Fig. 2.1
Schematic presentation of the immunological effects of silica particles, particularly on responder T cells and regulatory T cells, and the detection of various autoantibodies
Acknowledgments
The authors thank former colleagues in the Department of Hygiene, Kawasaki Medical School, namely, Prof. Ayako Ueki, Drs. Fuminori Hyodoh, Akiko Takata-Tomokuni, Yasuhiko Kawakami, Takaaki Aikoh, Shuko Murakami, and Yoshie Miura. We also appreciate the technical assistance of Ms. Haruko Sakaguchi, Naomi Miyahara, Minako Katoh, and Yumika Isozaki. We express special thanks to Drs. Masayasu Kusaka and Kozo Urakami for coordinating the collection of clinical samples. Part of the experimental results in this article was supported by the Special Coordination Fund for Promoting Science and Technology (H18-1-3-3-1, “Comprehensive approach on asbestos-related diseases”), KAKENHI grants (18390186, 19659153, 20390178, and 25460825), Kawasaki Medical School Project grants (20-410I, 23S5, 24S6, 25B65, and 27B06), the Sumitomo Foundation Grant (053027), the Yasuda Memorial Foundation Grant (H18), funding from the Takeda Science Foundation (I-2008) and Young Investigator Activating Grant from the Japanese Society of Hygiene (H18), the Ryobi Teien Memorial Foundation (H24), and the Kawasaki Foundation for Medical Science and Medical Welfare (H24).
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