rizatriptan

Class




  • Triptan




Rizatriptan


Commonly Prescribed for


(FDA approved in bold)



  • Migraine



Rizatriptan


How the Drug Works



  • Selective 5-HT1 receptor agonist, working predominantly at the B and D receptor subtypes. Effectiveness may be due to blocking the transmission of pain signals from the trigeminal nerve to the trigeminal nucleus caudalis and preventing release of inflammatory neuropeptides rather than just causing vasoconstriction



Rizatriptan


How Long Until It Works



  • 1 hour or less



Rizatriptan


If It Works



  • Continue to take as needed. Patients taking acute treatment more than 2 days/week are at risk for medication-overuse headache, especially if they have migraine



Rizatriptan


If It Doesn’t Work



  • Treat early in the attack – triptans are less likely to work after the development of cutaneous allodynia, a marker of central sensitization
  • For patients with partial response or reoccurrence, add an NSAID
  • Change to another agent



Rizatriptan


Best Augmenting Combos for Partial Response or Treatment-Resistance



  • NSAIDs or neuroleptics are often used to augment response



Rizatriptan


Tests



  • None required



Adverse Effects (AEs)




Rizatriptan


How Drug Causes AEs



  • Direct effect on serotonin receptors



Rizatriptan


Notable AEs



  • Tingling, flushing, sensation of burning, dizziness, sensation of pressure, palpitations, heaviness, nausea



Rizatriptan


Life-Threatening or Dangerous AEs



  • Rare cardiac events including acute MI, cardiac arrhythmias, and coronary artery vasospasm have been reported with rizatriptan



Rizatriptan


Weight Gain



  • Unusual



Rizatriptan


Sedation



  • Unusual



Rizatriptan


What to Do About AEs



  • In most cases, only reassurance is needed. Lower dose, change to another triptan or use an alternative headache treatment



Rizatriptan


Best Augmenting Agents for AEs



  • Treatment of nausea with antiemetics is acceptable. Other AEs improve with time


Dosing and Use




Rizatriptan


Usual Dosage Range



  • 5–10 mg, maximum 20 mg/day

Feb 16, 2017 | Posted by in PHARMACY | Comments Off on rizatriptan

Full access? Get Clinical Tree

Get Clinical Tree app for offline access