(FDA approved in bold)

• Hypertension
  
• Psychotic states
  
• Gilles de la Tourette syndrome (GTS) or tics
  
• Chorea and dyskinesias in Huntington’s disease
  
• Hemiballism
  
• Dystonia (especially tardive)
  
• Myoclonus

• Depleting agent that depletes stores of catecholamines (dopamine, norepinephrine) and serotonin in the brain and adrenal medulla. Depression of sympathetic nerve function lowers heart rate and blood pressure

• Hypertension – less than a week
  
• Psychosis, movement disorders – effects can be seen within a few days

• In neurologic conditions, continue to assess effect of the medication and determine if still needed

• Chorea: Consider benzodiazepines and anticonvulsants (valproate). Neuroleptics are usually effective. Tetrabenazine (another antiadrenergic) is often better tolerated
  
• Generalized dystonia: Anticholinergics, baclofen, or benzodiazepines may be effective. Surgical treatments (including pallidotomy, thalamotomy, deep brain stimulation, myotomy, rhizotomy, or peripheral denervation) are reserved for refractory cases
  
• GTS/tics – neuroleptics and alpha-2 adrenergic agonists are often effective

• AEs, such as CNS depression, often increase when used with other agents, but if tolerated consider combinations with anticonvulsants or benzodiazepines

• Monitor blood pressure and pulse