Rectal bleeding in a 45-year-old woman

Problem 19 Rectal bleeding in a 45-year-old woman






A sigmoidoscopic examination to 20 cm is normal. Proctoscopy confirms the presence of large internal haemorrhoids, which bleed easily on contact.



You explain to the patient that while the bleeding is most likely to be due to her haemorrhoids, a complete investigation of the large bowel is indicated. You arrange a colonoscopy. A lesion is found (Figure 19.1).




The tumour is indentified in the ascending colon. The colonoscopy was otherwise normal. The biopsy shows moderately differentiated adenocarcinoma.



Her haemoglobin is 100 g/L, her liver function tests and biochemistry are normal. A CT abdomen and chest is normal.



At operation a carcinoma of the ascending colon is found and a right hemicolectomy is performed. There is no evidence of adjacent or distant spread of the tumour. Apart from the tumour, there was nothing else abnormal in the resected specimen of bowel. There was no indication to perform a defunctioning ileostomy and she makes a good recovery. The histology is confirmed and the carcinoma involves the muscularis propria and extends into the pericolic fat. There is no perineural, vascular or lymph node involvement.



The patient understands that you will keep her under surveillance. She would like to know what this will involve.




The patient wants to know if any of her children are at risk for developing this cancer.


You explain to the patient that the risk to her children is slightly greater than it would be for the general population. Table 19.1 shows the risks.


Table 19.1 Risk factors in colorectal cancer















Family History Risk

Up to 2 fold

3 to 6 fold

1 in 2 lifetime

The patient’s son is with her. He understands that he is at slightly increased risk and would like to know what screening you would recommend for him. He is aged 23.



You advise him that if he is symptom free, he does not need any surveillance at this stage. If he does have symptoms, they should be investigated as appropriate. In any patient who has a positive occult blood test, it is recommended they have a colonoscopy. Similarly, you explain to him that any patient who presents with new rectal bleeding needs investigation. As a guiding rule, any patient who presents with an iron deficiency anaemia needs a full colonic investigation unless there are clear alternative causes such as menorrhagia.


The son has heard that ‘polyps in the bowel usually turn to cancer’.



The patient remains in good health and is kept under regular surveillance.



Answers


A.1 The patient has three symptoms that cause concern: increasing constipation, rectal blood loss and tiredness. You should ask further questions that may indicate why she is constipated. There are many possibilities in addition to colonic pathology, such as dietary changes, use of narcotic analgesia (codeine) or development of hypothyroidism. You should enquire about a personal history of polyps and family history of colon cancer. In the absence of an obvious cause for her constipation (confirmed by impacted faeces in the rectum), such as recent use of a codeine-containing compound, this patient will require examination of all of her large bowel. A sigmoidoscopy may be performed as part of the general physical examination and might clarify matters and identify a source for the bleeding in the anal canal or lower rectum. Even if the patient does have internal haemorrhoids, which may be the cause of the bleeding, she must be investigated further. Haemorrhoids are extremely common, but it is important to inspect the rest of the large intestine and so not overlook a tumour.


A.2 The most likely cause of bleeding in this type of patient is internal haemorrhoids, but it is essential to exclude a more sinister cause for the blood loss, especially as she has recently become constipated and tired for no obvious reason. Cancer of the colon, although more common in older patients, occurs in this age group and often presents with these symptoms. Despite the haemorrhoids, she must have a colonoscopy. In the absence of other symptoms and the visualization of a bleeding haemorrhoid it would be reasonable to treat the haemorrhoids and only investigate further if the symptoms persist. If a colonoscopy was not available (uncommon) then a barium enema would be an alternative but does not allow any diagnostic or therapeutic manoeuvres such as biopsy and snaring of polyps to be undertaken and if abnormal would require a colonoscopy for assesment and treatment.


A.3 This lesion has the typical appearance of an adenocarcinoma with raised, rolled edges and a central crater. The centre of the ulcer is likely to be ulcerated. The tumour occupies half the circumference of the bowel and is about 3 cm in length.


A.4 As part of the work-up, the following investigations are required:


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Apr 2, 2017 | Posted by in GENERAL SURGERY | Comments Off on Rectal bleeding in a 45-year-old woman

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