Reactive Nodular Fibrous Pseudotumor of Mesentery

Reactive Nodular Fibrous Pseudotumor of Mesentery

Elizabeth A. Montgomery, MD

Hematoxylin & eosin shows low magnification of a reactive nodular fibrous pseudotumor involving the mesentery extending up into the deep gastric submucosa.

Hematoxylin & eosin shows a higher magnification of the lesion. There are a few plasma cells along with fibroblastic cells and a collagenized background.



  • Lesion of mesentery composed of stellate and spindle-shaped cells arranged in collagen-rich stroma with lymphoid aggregates



  • Incidence

    • Rare

  • Age

    • Predominantly adults

  • Gender

    • No predominance


  • Obstruction

  • Frequent history of prior operations, evidence of prior bowel perforation, or history of pancreatitis

  • Some patients have multiple nodules

    • Some lesions associated with foreign bodies

  • Most in small bowel (ileal) mesentery

    • Also in colon mesentery and in bed of area of prior pancreatitis


  • Surgical excision


  • Excellent; benign process

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Reactive Nodular Fibrous Pseudotumor of Mesentery

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