Radiation Pneumonitis
Hakan Çermik
Mary L. Ostrowski
Roberto Barrios
Radiation-induced lung injury—acute, delayed, or chronic—is damage to the lung produced by ionizing radiation. Pathologic changes in radiated fields may follow as an acute radiation pneumonitis or may develop slowly after the radiation exposure. The main changes consist of thickened vessels, intimal fibrosis, and accumulations of foamy macrophages in pulmonary arteries and veins.
Cytologic Features
Single cells and occasional sheets of cells.
Increased cell size with normal or slightly increased nuclear-to-cytoplasmic ratio.
Degenerative nuclear chromatin with occasional nucleoli and abundant cytoplasm.
Histologic Features
Pattern of acute and organizing diffuse alveolar damage in acute radiation pneumonitis.
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