Pyloric Gland Adenoma
Vikram Deshpande, MD
Key Facts
Terminology
Benign neoplasm of glandular epithelium showing pyloric differentiation
Clinical Issues
Usually discovered incidentally
Macroscopic Features
Usually solitary sessile lesions
Microscopic Pathology
Well-demarcated nodules composed of closely packed pyloric-type glands with little intervening stroma
Lining epithelium shows basal nuclei with mucincontaining pale apical cytoplasm
Top Differential Diagnoses
Nodular hyperplasia of pseudopyloric glands
Ectopic gastric mucosa
Intestinal-type adenoma
 This pyloric gland adenoma forms a polypoid lesion in the lumen of the gallbladder composed of tightly packed pyloric-type glands. |
 High-power view demonstrates pyloric gland differentiation. Pyloric glands  are lined by cells with basal nuclei and pale cytoplasm. |
TERMINOLOGY
Abbreviations
Pyloric gland adenoma (PGA)
Synonyms
Tubular adenoma
Metaplastic adenoma
Definitions
Benign neoplasm of glandular epithelium showing pyloric gland differentiation
ETIOLOGY/PATHOGENESIS
Etiology Remains Speculative
Occasional PGAs have been reported in association with Peutz-Jeghers and Gardner syndrome
Current data suggest that PGAs are not a common pathway for development of gallbladder carcinoma
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