Plexiform Fibrohistiocytic Tumor



Plexiform Fibrohistiocytic Tumor


Cyril Fisher, MD, DSc, FRCPath










Low magnification shows plexiform fibrohistiocytic tumor (PFHT) at the dermal-subcutaneous interface with a plexiform appearance. Note the extensions into the dermis and subcutis.






Higher magnification shows a dermal ball-like (plexiform) growth pattern of histiocytoid cells as part of a histiocytictype of PFHT.


TERMINOLOGY


Abbreviations



  • Plexiform fibrohistiocytic tumor (PFHT)


Synonyms



  • Possibly represents deep form of cellular neurothekeoma


Definitions



  • Fibrohistiocytic tumor of intermediate malignant potential (rarely metastasizing)


  • Plexiform pattern



    • Cellular nodules; interlacing bands of fibroblasts


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare


  • Age



    • Children and young adults



      • Range: 1-77 years; median: 20 years


  • Gender



    • Slight male predominance


Site



  • Arises at dermal-subcutaneous junction



    • Extends into dermis and subcutis


  • Upper extremity is most common site


  • Followed by lower extremities and trunk


  • Rare in head and neck region


Presentation



  • Subcutaneous mass


Treatment

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Plexiform Fibrohistiocytic Tumor
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