Pharmacological Treatment of Acute and Chronic Post-traumatic Headache


5.1 Acute headache attributed to traumatic injury to the head

Diagnostic criteria:

A. Any headache fulfilling criteria C and D

B. Traumatic injury to the head1 has occurred

C. Headache is reported to have developed within 7 days after one of the following:

 1. The injury to the head

 2. Regaining of consciousness following the injury to the head

 3. Discontinuation of medication(s) that impair ability to sense or report headache following the injury to the head

D. Either of the following:

 1. Headache has resolved within 3 months after the injury to the head

 2. Headache has not yet resolved but 3 months have not yet passed since the injury to the head

E. Not better accounted for by another ICHD-3 diagnosis

5.1.2 Acute post-traumatic headache attributed to mild traumatic injury to the head

Diagnostic criteria:

A. Headache fulfilling criteria for 5.1 Acute headache attributed to traumatic injury to the head

B. Any headache fulfilling criteria C and D

C. Injury to the head fulfilling both of the following:

 1. Associated with none of the following:

  (a) Loss of consciousness for >30 min

  (b) Glasgow Coma Scale (GCS) score <13

  (c) Post-traumatic amnesia lasting >24 h

  (d) Altered level of awareness for >24 h

  (e) Imaging evidence of a traumatic head injury such as intracranial haemorrhage and/or brain contusion

 2. Associated, immediately following the head injury, with one or more of the following symptoms and/or signs:

  (a) Transient confusion, disorientation or impaired consciousness

  (b) Loss of memory for events immediately before or after the head injury

  (c) Two or more other symptoms suggestive of mild traumatic brain injury: nausea, vomiting, visual disturbances, dizziness and/or vertigo, impaired memory and/or concentration

D. Headache is reported to have developed within 7 days after one of the following:

 1. The injury to the head

 2. Regaining of consciousness following the injury to the head

 3. Discontinuation of medication(s) that impair ability to sense or report headache following the injury to the head

E. Either of the following:

 1. Headache has resolved within 3 months after the injury to the head

 2. Headache has not yet resolved but 3 months have not yet passed since the injury to the head

F. Not better accounted for by another ICHD-3 diagnosis

5.2. Persistent headache attributed to traumatic injury to the head

Diagnostic criteria:

A. Any headache fulfilling criteria C and D

B. Traumatic injury to the head 1 has occurred

C. Headache is reported to have developed within 7 days after one of the following:

 1. The injury to the head

 2. Regaining of consciousness following the injury to the head

 3. Discontinuation of medication(s) that impair ability to sense or report headache following the injury to the head

D. Headache persists for >3 months after the injury to the head

E. Not better accounted for by another ICHD-3 diagnosis.

5.2.2 Persistent headache attributed to mild traumatic injury to the head

A. Headache fulfilling criteria for 5.2 Persistent headache attributed to traumatic injury to the head

B. Head injury fulfilling both of the following:

 1. Associated with none of the following:

  (a) Loss of consciousness for >30 min

  (b) Glasgow Coma Scale (GCS) score <13

  (c) Post-traumatic amnesia lasting >24 h

  (d) Altered level of awareness for >24 h

  (e) Imaging evidence of a traumatic head injury such as intracranial haemorrhage and/or brain contusion

 2. Associated, immediately following the head injury, with one or more of the following symptoms and/or signs:

  (a) Transient confusion, disorientation or impaired consciousness

  (b) Loss of memory for events immediately before or after the head injury

  (c) Two or more other symptoms suggestive of mild traumatic brain injury: nausea, vomiting, visual disturbances, dizziness and/or vertigo, impaired memory and/or concentration



When a new headache occurs for the first time in close temporal relation to a known trauma, it is classified as a secondary headache attributed to the trauma. In the PTH, there has to be a close temporal relationship to the trauma. Thus, PTH has to begin within 7 days after injury to the head or after regaining consciousness. The 7-day interval is somewhat arbitrary and further research is needed to assess whether or not a different interval would be more appropriate. In the meantime, the ICHD-3 has also created appendix criteria for when the interval between injury and headache onset is greater than 7 days (delayed-onset headache attributed to traumatic injury to the head).

PTH is further divided into an acute and a persistent (previously called chronic) PTH. Acute PTH is defined as resolving within 3 months after the injury. Persistent PTH is defined as headache lasting more than 3 months after the injury (Table 17.1).

Both the acute and the persistent PTHs are then classified based upon the severity of the initial trauma in mild versus moderate and severe. There is no consensus about what characterizes the trauma that causes PTH except for the severity and the level of consciousness in the acute stage measured at the Glasgow Coma Scale. Within the trauma literature, multiple terms such as traumatic brain injury (TBI), head trauma, closed head injury, minor or minimal head injury, commotion or concussion have been applied and there is no clear consensus on the best term and definition. Still, there is also no evidence for an underlying brain injury after a mild injury to the head so the more descriptive term “head trauma” is consequently used in the following as in the opinion to the author we only have the history of a trauma to the head. For a clear debate and research strategy, the head trauma and the applied terms have to be clearly defined in the scientific community. More than 90 % of head trauma is classified as mild and the main body of literature is focused on PTH after a mild trauma.

The reason for these subdivisions is mainly practical as the underlying mechanisms most likely are different in the acute or persistent subforms. It seems also obvious for both patients and the society that a moderate or severe head trauma can cause headache whereas it is mystifying that a mild trauma, even without unconsciousness, can give rise to a debilitating persistent PTH. Several studies confirm the inverse relation between trauma severity and persistent PTH as patients with moderate to severe head trauma only rarely report persistent PTH.



17.3 Epidemiology and Disease Course


The prior controversies around the diagnostic criteria of PTH and the various definitions of head trauma had complicated the epidemiological research. In recent years, more reliable data have however been provided. In the USA at least 1.7 mio TBIs are annually reported and hereof 75 % are classified as concussions or mild head trauma. Internationally, similar incidences are reported with predominance in children, adolescents and young adults due to accidents, falls, combats and sport activities. Some patients may not even seek medical attention, and it is estimated that 20–40 % of people who have mild head injuries in the USA have not seeked treatment.

The vast majority resolve spontaneously over weeks most often with minimal or no treatment, so the exact number of mild head trauma and/or acute PTH is actually unknown.

In the military, it is estimated that more than 350,000 returning service members have sustained mild head injuries. The absolute prevalence of headache is unknown, but amongst those reporting blast injuries, greater than 90 % have headaches, mostly of the migraine type. Of all traumatic brain injuries (TBI) – causalities from Operation Enduring Freedom/Operation Iraqi Freedom up to 98 % report headaches in the acute phase, and 37 % still had headaches after 3 months observation period. In such combat situations, the circumstances and the intensities of the trauma may also be very different than in civil life so data are difficult to compare directly.

In the civilian populations, a prospective study by Kuczynski et al. in 670 children reported PTH in 11 % after 16 days and 7.8 % after 3 months. Others report acute PTH incidences at 1 month ranging from 31 to 90 %; at 3 months from 47 to 78 %; and at 1 year from 8.4 to 35 %. Twenty-four percent of patients have persisting headaches at 4 years in another study.
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Jul 22, 2016 | Posted by in PHARMACY | Comments Off on Pharmacological Treatment of Acute and Chronic Post-traumatic Headache

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