Drug
Evidence level
Dosage
Study design
References
Dose frequency
Flunazine
A
5–10 mg
DBPC; OL
Once per die
Topiramate
A
1–2 mg/kg
BDPC
Once per die
Valproate
B
15–45 mg/kg
OL; DBPC; rDBPC
Once/twice per die
Amitriptyline
C
0.25–1 mg/kg
RR, OL
Once per die
Propanolol
C
1–2 mg/kg
DBPC
Once per die
Pizotifen
C
0.5–1.5 mg/kg
DBPCCO
[26]
Once per die
References
1.
Brenner M, Lewis D (2008) The treatment of migraine headaches in children and adolescents. J Pediatr Pharmacol Ther 13(1):17–24
2.
O’Brien HL, Kabbouche MA, Kacperski J et al (2015) Treatment of pediatric migraine. Curr Treat Options Neurol 17(1):326
3.
Silberstein SD (2000) Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 55(6):754–762CrossRef
4.
Evers S, Afra J, Frese A et al (2006) EFNS guideline on the drug treatment of migraine – report of an EFNS task force. Eur J Neurol 13(6):560–572CrossRef
5.
Lanzi G, Balottin U, Zambrino CA et al (1996) Guidelines and recommendations for the treatment of migraine in paediatric and adolescent patients. Italian Society for the Study of Headache. Funct Neurol 11(5):269–275
6.
El-Chammas K, Keyes J, Thompson N et al (2013) Pharmacologic treatment of pediatric headaches: a meta-analysis. JAMA Pediatr 167(3):250–258CrossRef
7.
Autret A, Valade D, Debiais S (2012) Placebo and other psychological interactions in headache treatment. J Headache Pain 13(3):191–198CrossRef
8.
Sorge F, De Simone R, Marano E et al (1988) Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study. Cephalalgia 8(1):1–6CrossRef
9.
Guidetti V, Moscato D, Ottaviano S et al (1987) Flunarizine and migraine in childhood. An evaluation of endocrine function. Cephalalgia 7(4):263–266CrossRef
10.
Lewis DW, Winner P (2006) The pharmacological treatment options for pediatric migraine: an evidence-based appraisal. NeuroRx 3(2):181–191CrossRef
11.
Oakley CB, Kossoff EH (2014) Migraine and epilepsy in the pediatric population. Curr Pain Headache Rep 18(3):402CrossRef
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