Pharmacokinetics: metabolism and excretion

4 Pharmacokinetics

metabolism excretion

Drug metabolism

The liver is the major organ for the biotransformation of drugs. Hepatic cytochrome P450 (CYP) actively metabolizes endogenous and exogenous chemicals to metabolites that are, in general, more polar; this promotes elimination from the body and terminates drug action. In some cases, the metabolite may itself have potent biological activity or have toxic properties. Essentially, two types of biotransformation can occur.

Jul 18, 2016 | Posted by in PHARMACY | Comments Off on Pharmacokinetics: metabolism and excretion

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