Pedigrees


Figure 7-2 Symbols commonly used in pedigree charts. Although there is no uniform system of pedigree notation, the symbols used here are according to recent recommendations made by professionals in the field of genetic counseling.


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Figure 7-3 Relationships within a kindred. The proband, III-5 (arrow), represents an isolated case of a genetic disorder. She has four siblings, III-3, III-4, III-7, and III-8. Her partner/spouse is III-6, and they have three children (their F1 progeny). The proband has nine first-degree relatives (her parents, siblings, and offspring), nine second-degree relatives (grandparents, uncles and aunts, nieces and nephews, and grandchildren), two third-degree relatives (first cousins), and four fourth-degree relatives (first cousins once removed). IV-3, IV-5, and IV-6 are second cousins of IV-1 and IV-2. IV-7 and IV-8, whose parents are consanguineous, are doubly related to the proband: second-degree relatives through their father and fourth-degree relatives through their mother.

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Nov 27, 2016 | Posted by in GENERAL & FAMILY MEDICINE | Comments Off on Pedigrees

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