Pancreatic Intraepithelial Neoplasia



Pancreatic Intraepithelial Neoplasia


Vikram Deshpande, MD









This example of PanIN-1 shows a pancreatic duct lined by a single layer of epithelium with abundant apical mucinous cytoplasm and basal nuclei that lack atypia.






This example of PanIN-2 shows a pancreatic duct lined by a micropapillary proliferation of mucinous epithelial cells. Focally, a loss of nuclear polarity is present image.


TERMINOLOGY


Abbreviations



  • Pancreatic intraepithelial neoplasia (PanIN)


Synonyms



  • Metaplasia, dysplasia, carcinoma in situ


Definitions



  • Noninvasive pancreatic ductal epithelial proliferations that are associated with pancreatic ductal adenocarcinoma


CLINICAL ISSUES


Natural History



  • PanIN-1: Commonly found in resected pancreata; significance unclear


  • PanIN-3: Associated with significant risk of progression to pancreatic ductal adenocarcinoma


Treatment

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Pancreatic Intraepithelial Neoplasia
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