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 Figure 1.1.1 Columnar cell lesion without atypia: The lobular unit is enlarged and consists of dilated acini with undulating contours. The intralobular connective tissue is fibrotic. |
 Figure 1.1.2 The dilated acini contain secretions and are lined by a single layer of columnar cells; the relationship with the myoepithelial cell layer is orderly in columnar cell lesions without atypia. |
 Figure 1.1.3 The columnar cells maintain basolateral polarity. Nuclei are small, without obvious nucleoli. The myoepithelial cells are prominent. |
 Figure 1.1.4 Cystically dilated lobular unit: Half of the acini of this lobular unit are expanded, but maintain rounded contours. |
 Figure 1.1.5 The dilated acini contain translucent secretions and lack histiocyes or inflammatory cells. Acini of normal size and configuration are present adjacent to the dilated acini. |
 Figure 1.1.6 The cystically dilated acini are lined by a single layer of normally polarized, low cuboidal epithelium, with patchy attenuation. |
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 Figure 1.2.1 Columnar cell lesion without atypia. Most acini in the lobular unit are enlarged and have irregular contours. |
 Figure 1.2.2 The enlarged acini contain calcifying secretions and a single columnar luminal epithelial cell layer. |
 Figure 1.2.3 The acinar cells are distinctly elongated and have prominent apical snouts. |
 Figure 1.2.6 Columnar cell lesion with atypia: Two adjacent lobular units contain several enlarged, dilated acini. At low power, the character of the lining cells is not evident. |
 Figure 1.2.7 At higher power, the “globoid” nature of the dilated acini is evident in columnar cell lesions with atypia. |
 Figure 1.2.8 Columnar cell lesion with atypia: These dilated acini contain secretions and are lined by cells with rounded nuclei with an increased nuclear to cytoplasmic ratio. |
 Figure 1.2.4 The columnar lining cells maintain normal basolateral polarity. The myoepithelial layer is regularly identifiable. |
 Figure 1.2.5 Although an occasional cellular bridge is noted, the nuclei are overlapping with their long axes oriented parallel with the bar, diagnostic criterion for usual hyperplasia. Focal pseudostratification or tangential sectioning may create the appearance of multiple cell layers and loss of polarity. |
 Figure 1.2.9 The acini are lined by several layers of luminal epithelial cells with loss of a polar arrangement. Myoepithelial cells are present, but not prominent. Apocrine snouts are observed in most acini. Note the conspicuous absence of architectural features diagnostic of ADH i.e., cribriform spaces, bars, or bulbous papillae. |
 Figure 1.2.10 In addition to loss of polarity, the nuclei have readily apparent nucleoli; compare with the adjacent acinus lined by a single layer of smaller nuclei (left side). |
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