TABLE 15.1 Nonneoplastic Disease of the Larynx
sheets of multinucleated foreign body-type giant cells that contain birefringent clear material are present with intermixed chronic inflammation and fibrosis (Fig. 15.3, eFigs. 15.4 and 15.5). Other material, including silicone, Gore-Tex, and titanium, may be used for vocal cord
medialization.9,10 These foreign materials are generally not absorbed and induce surrounding fibrosis and chronic inflammation with a variable foreign body reaction.
histologic features of tuberculosis found elsewhere with caseating granulomatous inflammation and Langhans giant cells (Fig. 15.4, eFig. 15.6).15 Histochemical and immunohistochemical staining for acid-fast bacilli can sometimes be helpful given the differential that must be considered (Table 15.2).
FIGURE 15.4 Laryngeal tuberculosis appears similar to tuberculosis seen at other sites in the body with necrotizing granulomatous inflammation.
TABLE 15.2 Granulomatous Disease of the Larynx
seen with mixed inflammation and giant cells, with or without well-formed granulomata. The characteristic spherules and endospores of the organisms can be seen both by conventional H&E stain and with silver or PAS stains.
FIGURE 15.5 Intracellular organisms consistent with Histoplasma are seen in this case of laryngeal infection.
FIGURE 15.7 Surface erosion with numerous pseudohyphae is seen in this case of laryngeal candidiasis.