Nevus Lipomatosus
Steven D. Billings, MD
Key Facts
Terminology
Connective tissue nevus characterized by mature adipose tissue in reticular dermis
Clinical Issues
Solitary or multiple grouped papules or polypoid lesions
Microscopic Pathology
Mature adipose tissue in upper dermis
Absence of adnexal structures
Top Differential Diagnoses
Acrochordon (skin tag)
Lacks mature adipose tissue
Lipoma
Fibrolipoma
Spindle cell lipoma
Focal dermal hypoplasia
Clinically different
 Nevus lipomatosus often appears polypoid and consists of mature fat within the dermis. |
 The aggregates of mature adipose tissue  are often found around dermal blood vessels  . |
TERMINOLOGY
Synonyms
Nevus lipomatosus superficialis
Pedunculated lipofibroma
Definitions
Connective tissue nevus/hamartoma characterized by mature adipose tissue in reticular dermis
ETIOLOGY/PATHOGENESIS
Unknown
Most cases are idiopathic
Genetic
Single case described with 2p24 deletion
Importance in pathogenesis remains unclear
