Myelolipoma

Myelolipoma
Cyril Fisher, MD, DSc, FRCPath
Key Facts
Terminology
  • Tumor-like lesion resembling bone marrow composed of hemopoietic tissues, fat, and sometimes bone
  • Most cases involve adrenal gland
  • Rarely other sites
Clinical Issues
  • Older adults, usually after 4th decade
Microscopic Pathology
  • Circumscribed, nonencapsulated
  • Rim of adrenal cortex
  • Fat without atypia or lipoblasts
  • Hemopoietic elements
    • All 3 cell lines represented
Diagnostic Checklist
  • Typically circumscribed adrenal mass
Hematoxylin & eosin shows scanning magnification appearance of myelolipoma. Adrenal glandular tissue is stretched around a circumscribed, nonencapsulated lesion that displays fatty and cellular areas.
CT shows a predominantly fatty mass image replacing and expanding the left adrenal gland. The left kidney image is displaced. These imaging appearances are characteristic of an adrenal myelolipoma.
TERMINOLOGY
Definitions
  • Tumor-like lesion resembling bone marrow composed of hemopoietic tissues, fat, and sometimes bone
  • Mostly in adrenal gland
  • Rarely other sites
ETIOLOGY/PATHOGENESIS
Associated Conditions
  • Cortical adenoma, pheochromocytoma
  • Adrenal cortical hyperplasia
    • Possible effect on hemopoietic stem cell rests
  • Most are idiopathic
CLINICAL ISSUES
Epidemiology
  • Incidence
    • Rare
  • Age
    • Older adults, usually after 4th decade
  • Gender
    • M = F
Site
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Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Myelolipoma

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