Molecular Factors Discussed

Molecular Factor

Chromosomal Location

Definition/Alternative Names

Chapters

β-catenin (see CTNNB1)

10p, loss of

10p

Childhood Melanoma

10q, loss of

10q

Childhood Melanoma; Perineurioma

11p, gain of

11p

Atypical/Borderline and Malignant Spitz Tumors; Childhood Melanoma; Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

11p15.5

11p15.5

Cutaneous Rhabdomyosarcoma

11q, loss of

11q

Childhood Melanoma

11q12

11q12

Collagenous Fibroma

11q13-21

11q13-21

Hibernoma

12p, loss of

12p

Blastic Plasmacytoid Dendritic Cell Neoplasm

12q13-15

12q13-15

Lipoma; Atypical Lipomatous Tumor and Liposarcoma

13q, loss of

13q

Blastic Plasmacytoid Dendritic Cell Neoplasm; Lipoma; Spindle Cell and Pleomorphic Lipoma

13q14

13q14

Angiomyofibroblastoma

15q, loss of

15q

Blastic Plasmacytoid Dendritic Cell Neoplasm

16p13.3

16p13.3

TSC2

PEComas

16q, loss of

16q

Spindle Cell and Pleomorphic Lipoma

17q, gain of

17q

Childhood Melanoma

17q11

17q11

NF1

Superficial Malignant Peripheral Nerve Sheath Tumor

17q11.2

17q11.2

Neurofibroma

17q13

17q13

P53

Superficial Malignant Peripheral Nerve Sheath Tumor

18q11

18q11

Epithelioid Sarcoma

18q21.31-33

18q21.31-33

Diffuse Large B-cell Lymphoma, Leg Type

1p, alterations of

1p

Angioimmunoblastic T-cell Lymphoma

1p13

1p13

CSF1

Giant Cell Tumor of Tendon Sheath

1p21-22

1p21-22

Glomus Tumors

1p36

1p36

Primary Neuroendocrine (Merkel Cell) Carcinoma

1q, gain of

1q

Childhood Melanoma; Sinonasal Melanoma

20q, gain of

20q

Childhood Melanoma

22q, alterations of

22q

Epithelioid Sarcoma

2p23

2p23

ALK

Primary Cutaneous Anaplastic Large Cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

3p11-12

3p11-12

Myxoinflammatory Fibroblastic Sarcoma

5q, loss of

5q

Blastic Plasmacytoid Dendritic Cell Neoplasm

6p, gain of

6p, gain of

Childhood Melanoma; Sinonasal Melanoma

6p21-23

6p21-23

Lipoma

6q, loss of

6q

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Childhood Melanoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

7p, gain of

7p

Childhood Melanoma

7q, gain of

7q

Childhood Melanoma

7q, isochromosome

i(7q)

Intravascular large B-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

7q22-36

7q22-36

Intravascular large B-cell Lymphoma

8q, gain of

8q, gain of

Childhood Melanoma; Sinonasal Melanoma

9p, loss of

9p, loss of

Childhood Melanoma

9q, loss of

9q, loss of

Childhood Melanoma

9q34

9q34

TSC1

PEComas; Systemic T-cell and NK-cell Lymphomas Involving the Skin

ALK

2p23

Histiocytic Sarcoma; Lymphomatoid Papulosis; Primary Cutaneous Anaplastic Large Cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

ANTXR2

4q21.21

anthrax toxin receptor 2

Juvenile Hyaline Fibromatosis

AP12/MLT

t(11;18)(q21;q21)

Cutaneous Marginal Zone B-cell Lymphoma

APC

5q21

adenomatosis polyposis coli

Fibromatosis; Myofibroma and Myofibromatosis

API2

11q22

apoptosis inhibitor 2; BIRC3

Systemic B-cell Lymphomas Involving the Skin

ATF1

12q13

activating transcription factor 1

Myxoinflammatory Fibroblastic Sarcoma

ATIC

2q35

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

Primary Cutaneous Anaplastic Large Cell Lymphoma

BAX

19q13.3-q13.4

BCL2-associated X protein

Basal Cell Carcinoma

BCL10

1p22

B-cell CLL/lymphoma 10

Systemic B-cell Lymphomas Involving the Skin

BCL2

18q21.3

B-cell CLL/lymphoma 2

Diffuse Large B-cell Lymphoma, Leg Type; Histiocytic Sarcoma; Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

BCL6

3q27

B-cell CLL/lymphoma 6

Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type

BMI1

10p11.23

polycomb ring finger oncogene

Basal Cell Carcinoma

BRAF

7q34

v-raf murine sarcoma viral oncogene homolog B1

Common Acquired Melanocytic Nevi

C11orf95-MKL2

16p13.12

myocardin-like 2

Chondroid Lipoma

CCND1

11q13

cyclin D1; BCL1

Systemic B-cell Lymphomas Involving the Skin

CDK4

12q14

cyclin-dependent kinase 4

Atypical Lipomatous Tumor and Liposarcoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma

CDKN2A

9p21

cyclin-dependent kinase inhibitor 2A;p16INK4A

Childhood Melanoma; Diffuse Large B-cell Lymphoma, Leg Type; Mycosis Fungoides (and Subtypes)

CDKN2B

9p21

cyclin-dependent kinase inhibitor 2B;p15INK4b

Diffuse Large B-cell Lymphoma, Leg Type

CHOP

Cutaneous Gamma-Delta T-cell Lymphoma

Chromosome 1, alterations of

1

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor; Primary Neuroendocrine (Merkel Cell) Carcinoma;

Chromosome 10, alterations of

10

Perineurioma

Chromosome 11, alterations of

11

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

Chromosome 12, gain of

12

Cutaneous Rhabdomyosarcoma; Systemic B-cell Lymphomas Involving the Skin

Chromosome 13, gain of

13

Cutaneous Rhabdomyosarcoma

Chromosome 17, alterations of

17

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

Chromosome 18, gain of

18

Systemic B-cell Lymphomas Involving the Skin

Chromosome 2, alterations of

2

Primary Cutaneous Anaplastic Large Cell Lymphoma

Chromosome 2, gain of

2

Cutaneous Rhabdomyosarcoma;

Chromosome 22, alterations of

22

Perineurioma; Schwannoma (Neurilemmoma)

Chromosome 3, gain of

3

Systemic B-cell Lymphomas Involving the Skin

Chromosome 6, alterations of

6

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

Chromosome 8, alterations of

8

Leukemia Cutis

Chromosome 8, gain of

8

Cutaneous Rhabdomyosarcoma; Systemic B-cell Lymphomas Involving the Skin

c-KIT (see KIT)

CLTC

17q11-qter

clathrin, heavy chain

Primary Cutaneous Anaplastic Large Cell Lymphoma

c-MYC (see MYC)

COL1A1-PDGFB

t(17;22)(q22;q13)

COL1A1-PDGFβ

Fibrosarcoma; Superficial Malignant Peripheral Nerve Sheath Tumor

CREB3L1

11p11.2

cAMP responsive element binding protein 3-like 1

Low-Grade Fibromyxoid Sarcoma (Evans Tumor)

CREB3L2

7q34

cAMP responsive element binding protein 3-like 2

Low-Grade Fibromyxoid Sarcoma (Evans Tumor)

CSF1

1p21-p13

colony stimulating factor 1

Giant Cell Tumor of Tendon Sheath

CTNNB1

3p21

β-catenin; beta-catenin

Extranodal NK/T-cell Lymphoma, Nasal Type; Fibromatosis; Myofibroma and Myofibromatosis; Pilomatrixoma and Pilomatrical Carcinoma

CYLD

16q12.1

cylindromatosis (turban tumor syndrome)

Cylindroma

del(11q)

11q

Systemic B-cell Lymphomas Involving the Skin

del(13q)

13q

Systemic B-cell Lymphomas Involving the Skin

del(17p)

17p

Systemic B-cell Lymphomas Involving the Skin

del(6)

6

Systemic B-cell Lymphomas Involving the Skin

del(6)(q21q25)

6q21-25

Extranodal NK/T-cell Lymphoma, Nasal Type

del(6q21)

6q21

Systemic B-cell Lymphomas Involving the Skin

EBER

EBV-encoded small nuclear RNA

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Gamma-Delta T-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Extranodal NK/T-cell Lymphoma, Nasal Type; Histiocytic Sarcoma; Lymphomatoid Papulosis; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma

ETV6-NTRK3

t(12;15)(p13;q26)

Fibrosarcoma

EVER1/TMC6

17q25.3

transmembrane channel-like 6; epidermodysplasia verruciformis 1

Epidermodysplasia Verruciformis (EDV)

EVER2/TMC8

17q25.3

transmembrane channel-like 8; epidermodysplasia verruciformis 2

Epidermodysplasia Verruciformis (EDV)

EWS

22q12.2

Ewing sarcoma

Myxoinflammatory Fibroblastic Sarcoma

EWS-ATF1

t(12;22)(q13;q12)

Epithelioid Sarcoma; Fibromatosis; Myxoinflammatory Fibroblastic Sarcoma; PEComas; Superficial Malignant Peripheral Nerve Sheath Tumor

EWS-CREB1

t(2;22)(q33;q12)

Myxoinflammatory Fibroblastic Sarcoma; PEComas; Superficial Malignant Peripheral Nerve Sheath Tumor

EWS-FLI1

t(11;22)(q24;q12)

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

EWSR1-CREB1

t(2;22)(q33;q12)

Angiomatoid Fibrous Histiocytoma

FAS

10q24.1

TNF receptor superfamily, member 6; CD95

Cutaneous Marginal Zone B-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type

FIP1L1-PDGFRA

4q12

FIP1L1-PDGFRα; del(4)(q12)

Cutaneous and Systemic Mastocytosis

FOXC2

16q24.1

forkhead box C2; MFH1

Lymphangioma and Superficial Lymphangioma

FOXO1

13q14.1

forkhead box O1; FKHR; FOXO1A

Angiomatoid Fibrous Histiocytoma; Cutaneous Rhabdomyosarcoma

FOXP1

3p14.1

forkhead box P1

Diffuse Large B-cell Lymphoma, Leg Type

FUS

16p11.2

fused in sarcoma

Low-Grade Fibromyxoid Sarcoma (Evans Tumor)

FUS-ATF1

t(12;16)(q13;p11)

Angiomatoid Fibrous Histiocytoma

FUS-CREB3L2

t(7;16)(q34;p11)

Fibromatosis

GNA11

19p13.3

guanine nucleotide binding protein (G protein), alpha 1

Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus)

GNAQ

9q21

guanine nucleotide binding protein (G protein), q polypeptide

Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus)

i(6)(p10)

i(6)(p10)

Extranodal NK/T-cell Lymphoma, Nasal Type

i(8)(q10)

i(8)(q10)

Systemic T-cell and NK-cell Lymphomas Involving the Skin

IGH

14q32.33

Immunoglobulin heavy chain gene

Angioimmunoblastic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Cutaneous Plasmacytoma; Diffuse Large B-cell Lymphoma, Leg Type; Extranodal NK/T-cell Lymphoma, Nasal Type; Histiocytic Sarcoma; Intravascular large B-cell Lymphoma; Lymphomatoid Granulomatosis; Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

IGH-BCL2

t(14;18)(q32;q21)

Diffuse Large B-cell Lymphoma, Leg Type

IGHV

14q32.33

Immunoglobulin heavy chain variable region

Diffuse Large B-cell Lymphoma, Leg Type

immunoglobulin heavy chain gene

14q32.33

IGH

Cutaneous Gamma-Delta T-cell Lymphoma; Primary Cutaneous Follicle Center Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma

INK4A

9p21

p16INK4A; CDKN2A

Superficial Malignant Peripheral Nerve Sheath Tumor

inv(14)(q11q32)

inv(14)(q11q32)

Systemic T-cell and NK-cell Lymphomas Involving the Skin

inv(2)(p23;q35)

inv(2)(p23;q35)

Primary Cutaneous Anaplastic Large Cell Lymphoma

IRF4

6p25-p23

interferon regulatory factor 4

Systemic T-cell and NK-cell Lymphomas Involving the Skin

Isochromosome 12

i(12)

Histiocytic Sarcoma

Ki-67

10q26.2

MKI67

Diffuse Large B-cell Lymphoma, Leg Type; Kaposi Sarcoma; Systemic B-cell Lymphomas Involving the Skin

KIT

4q11-q12

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117

Cutaneous and Systemic Mastocytosis; Cutaneous and Systemic Mastocytosis; Extranodal NK/T-cell Lymphoma, Nasal Type; Fibromatosis; Mucosal Melanoma (Genital); Oral Melanoma; PEComas

KRAS

12p12.1

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Extranodal NK/T-cell Lymphoma, Nasal Type

MALT1

18q21

mucosa associated lymphoid tissue lymphoma translocation gene 1

Diffuse Large B-cell Lymphoma, Leg Type; Systemic B-cell Lymphomas Involving the Skin

MDM2

12q15

p53 binding protein homolog (mouse)

Atypical Lipomatous Tumor and Liposarcoma; Cutaneous Malignant Fibrous Histiocytoma/Pleomorphic Sarcoma

MET

7q31

proto-oncogene (hepatocyte growth factor receptor); c-MET

Cutaneous and Systemic Mastocytosis

MIC2

Xp22.32 & Yp11.3

CD99

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

MLH1

3p21.3

mutL homolog 1

Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma

MLT1 (see MALT1)

Monosomy 10

10

Perineurioma

Monosomy 9

9

Blastic Plasmacytoid Dendritic Cell Neoplasm

MSH2

2p21

mutS homolog 2

Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma

MSH6

2p16

mutS homolog 6

Sebaceoma (Sebaceous Epithelioma); Sebaceous Carcinoma

MSI

Microsatellite Instability

Sebaceous Carcinoma

MSN

Xq11.1

moesin

Primary Cutaneous Anaplastic Large Cell Lymphoma

MUM1

6p25-p23

multiple myeloma oncogene 1; IRF4

Blastic Plasmacytoid Dendritic Cell Neoplasm; Diffuse Large B-cell Lymphoma, Leg Type; Systemic B-cell Lymphomas Involving the Skin

MYC

8q24

v-myc myelocytomatosis viral oncogene homolog;c-MYC

Atypical Vascular Lesion; Atypical Vascular Lesion; Blastic Plasmacytoid Dendritic Cell Neoplasm; Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Systemic B-cell Lymphomas Involving the Skin

MYH9

22q13.1

myosin, heavy chain 9, non-muscle

Primary Cutaneous Anaplastic Large Cell Lymphoma

ND

Primary Cutaneous Anaplastic Large Cell Lymphoma

NF1

17q11.2

neurofibromin 1

Neurofibroma; Schwannoma (Neurilemmoma); Superficial Malignant Peripheral Nerve Sheath Tumor

NF2

22q12.2

neurofibromin 2

Perineurioma; Schwannoma (Neurilemmoma)

NPM

5q35

Nucleophosmin

Primary Cutaneous Anaplastic Large Cell Lymphoma

NRAS

1p13.2

neuroblastoma RAS viral (v-ras) oncogene homolog

Mucosal Melanoma (Genital); Oral Melanoma

P15

9p21

CDKN2B

Primary Cutaneous Follicle Center Lymphoma;

P16

9p21

CDKN2A

Mycosis Fungoides (and Subtypes); Penile and Vulvar Intraepithelial Neoplasia; Primary Cutaneous Follicle Center Lymphoma; Syringocystadenoma Papilliferum

P53

17p13.1

TP53

Actinic Keratosis; Basal Cell Carcinoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Penile and Vulvar Intraepithelial Neoplasia; Superficial Malignant Peripheral Nerve Sheath Tumor; Superficial Malignant Peripheral Nerve Sheath Tumor

PAX3

2q35

paired box 3

Cutaneous Rhabdomyosarcoma

PAX3/7

2q35 & 1p36.13

paired box 3/7

Angiomatoid Fibrous Histiocytoma

PAX5

9p13

paired box 5

Systemic B-cell Lymphomas Involving the Skin

PAX7

1p36.13

paired box 7

Cutaneous Rhabdomyosarcoma

PROX1

1q41

prospero homeobox 1

Lymphangioma and Superficial Lymphangioma

PTCH (see PTCH1)

PTCH1

9q22.3

patched 1

Basal Cell Carcinoma; Cutaneous Keratocyst; Nevus Sebaceus and Follicular Hamartomas; Rhabdomyoma; Syringocystadenoma Papilliferum

PTEN

10q23.31

phosphatase and tensin homolog

Fibrolipomatous Hamartoma of Nerve; Mycosis Fungoides (and Subtypes); Tricholemmoma

REL

2p13-p12

v-rel reticuloendotheliosis viral oncogene homolog; c-REL

Primary Cutaneous Follicle Center Lymphoma

RMRP

9p21-p12

RNA component of mitochondrial RNA processing endoribonuclease

Basal Cell Carcinoma

SAS

12q13.3

sarcoma-amplified sequence

Atypical Lipomatous Tumor and Liposarcoma

SOX18

20q13.33

SRY (sex determining region Y)-box 18

Lymphangioma and Superficial Lymphangioma

SOX9

17q23

SRY (sex-determining region Y)-box 9 protein

Basal Cell Carcinoma

t(1;10)

t(1;10)

Myxoinflammatory Fibroblastic Sarcoma

t(1;13)

t(1;13)

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

t(1;13)(p36;q14)

t(1;13)(p36;q14)

Cutaneous Rhabdomyosarcoma

t(1;14)(p22;q32)

t(1;14)(p22;q32)

IGH-BCL10

Systemic B-cell Lymphomas Involving the Skin

t(1;2)(q25;p23)

t(1;2)(q25;p23)

Primary Cutaneous Anaplastic Large Cell Lymphoma

t(10;22)

t(10;22)

Epithelioid Sarcoma

t(11;14)

t(11;14)

Primary Cutaneous Follicle Center Lymphoma

t(11;14)(q13;q32)

t(11;14)(q13;q32)

IGH-CCND1

Systemic B-cell Lymphomas Involving the Skin

t(11;16)

t(11;16)

Collagenous Fibroma

t(11;16)(p11;p11)

t(11;16)(p11;p11)

FUS-CREB3L1

Low-Grade Fibromyxoid Sarcoma (Evans Tumor)

t(11;16)(q13;p12-13)

t(11;16)(q13;p12-13)

Chondroid Lipoma

t(11;18)

t(11;18)

Cutaneous Marginal Zone B-cell Lymphoma

t(11;18)(q21;q32)

t(11;18)(q21;q32)

API2-MLT1

Systemic B-cell Lymphomas Involving the Skin

t(11;22)

t(11;22)

Epithelioid Sarcoma

t(11;22)(q24;q12)

t(11;22)(q24;q12)

EWS-FLI1

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

t(12:22)

t(12:22)

Superficial Malignant Peripheral Nerve Sheath Tumor

t(12;15)(p13;q26)

t(12;15)(p13;q26)

ETV6-NTRK3

Fibrosarcoma

t(12;16)

t(12;16)

Chondroid Lipoma; Hibernoma

t(12;16)(q13;p11)

t(12;16)(q13;p11)

FUS-ATF1

Epithelioid Hemangioendothelioma

t(12;22)

t(12;22)

Chondroid Lipoma; Hibernoma

t(14;14)(q11;q32)

t(14;14)(q11;q32)

Systemic T-cell and NK-cell Lymphomas Involving the Skin

t(14;18)

t(14;18)

Blastic Plasmacytoid Dendritic Cell Neoplasm; Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Histiocytic Sarcoma; Primary Cutaneous Follicle Center Lymphoma; Systemic B-cell Lymphomas Involving the Skin

t(14;18)(q32;q21)

t(14;18)(q32;q21)

IGH-MLT1

Cutaneous Marginal Zone B-cell Lymphoma; Diffuse Large B-cell Lymphoma, Leg Type; Histiocytic Sarcoma; Primary Cutaneous Follicle Center

Lymphoma; Systemic B-cell Lymphomas Involving the Skin

t(17;22)(q22;q13)

t(17;22)(q22;q13)

COL1A1-PDGFβ

Superficial Malignant Peripheral Nerve Sheath Tumor

t(2;10)(p23;q24)

t(2;10)(p23;q24)

Perineurioma

t(2;11)(q31;q12)

t(2;11)(q31;q12)

Collagenous Fibroma

t(2;13)

t(2;13)

Peripheral Neuroepithelioma/Primitive Neuroectodermal Tumor

t(2;13)(q35;q14)

t(2;13)(q35;q14)

PAX3-FKHR

Cutaneous Rhabdomyosarcoma

t(2;17)(p23;q23)

t(2;17)(p23;q23)

Primary Cutaneous Anaplastic Large Cell Lymphoma

t(2;17)(p23;q25)

t(2;17)(p23;q25)

Primary Cutaneous Anaplastic Large Cell Lymphoma

t(2;19)(p23;p13.1)

t(2;19)(p23;p13.1)

Primary Cutaneous Anaplastic Large Cell Lymphoma

t(2;22)(p23;q11.2)

t(2;22)(p23;q11.2)

Primary Cutaneous Anaplastic Large Cell Lymphoma

t(2;3)(p23;q12)

t(2;3)(p23;q12)

Primary Cutaneous Anaplastic Large Cell Lymphoma

t(2;5)

t(2;5)

Systemic T-cell and NK-cell Lymphomas Involving the Skin

t(2;5)(p23;q35)

t(2;5)(p23;q35)

ALK-NPM

Lymphomatoid Papulosis; Primary Cutaneous Anaplastic Large Cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

t(2;6)(q31;p21.3)

t(2;6)(q31;p21.3)

Myxoinflammatory Fibroblastic Sarcoma

t(2;8)

t(2;8)

MYC-kappa

Systemic B-cell Lymphomas Involving the Skin

t(7;16)

t(7;16)

Collagenous Fibroma

t(7;16)(q32-34;p11)

t(7;16)(q32-34;p11)

FUS-CREB3L2

Low-Grade Fibromyxoid Sarcoma (Evans Tumor); Fibrosarcoma

t(8;14)

t(8;14)

Blastic Plasmacytoid Dendritic Cell Neoplasm

t(8;14)(q22.3;q13)

t(8;14)(q22.3;q13)

Vascular Hamartomas

t(8;22)

t(8;22)

MYC-lambda

Systemic B-cell Lymphomas Involving the Skin

t(8;22)(q22;q11)

t(8;22)(q22;q11)

Epithelioid Sarcoma

t(8;8)(p12;q11)

t(8;8)(p12;q11)

Systemic T-cell and NK-cell Lymphomas Involving the Skin

t(9;11)(q34;q13)

t(9;11)(q34;q13)

Hibernoma

t(9;17)

t(9;17)

Chondroid Lipoma

t(9;17)(q22;q11)

t(9;17)(q22;q11)

NR4A3-TAF2N

Epithelioid Hemangioendothelioma

t(9;22)

t(9;22)

Chondroid Lipoma

t(9;22)(q22;q12)

t(9;22)(q22;q12)

EWSR1-NR4A3

Epithelioid Hemangioendothelioma

t(X;14)(q28;q11)

t(X;14)(q28;q11)

Systemic T-cell and NK-cell Lymphomas Involving the Skin

t(X;18)(p11;q11)

t(X;18)(p11;q11)

Fibrosarcoma

t(X;2)(q11-12;p23)

t(X;2)(q11-12;p23)

MSN-ALK

Primary Cutaneous Anaplastic Large Cell Lymphoma

T-cell receptor gamma gene

7p14

TCRγ

Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma; Blastic Plasmacytoid Dendritic Cell Neoplasm; Subcutaneous Panniculitis-like T-cell Lymphoma

T-cell receptor gene

TCR

Lymphomatoid Granulomatosis; Lymphomatoid Papulosis

TCL1A

14q32.1

T-cell leukemia/lymphoma 1A

Systemic T-cell and NK-cell Lymphomas Involving the Skin

TCR

T-cell receptor gene

Angioimmunoblastic T-cell Lymphoma; Extranodal NK/T-cell Lymphoma, Nasal Type; Intravascular large B-cell Lymphoma; Mycosis Fungoides (and Subtypes); Primary Cutaneous CD4+ Small/Medium Pleomorphic T-cell Lymphoma; Subcutaneous Panniculitis-like T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

TCRβ

7q34

T-cell receptor beta gene

Cutaneous Gamma-Delta T-cell Lymphoma

TCRγ

7p14

T-cell receptor gamma gene

Cutaneous Gamma-Delta T-cell Lymphoma

TCRδ

4q11.2

T-cell receptor delta gene

Cutaneous Gamma-Delta T-cell Lymphoma

TET2

4q24

tet methylcytosine dioxygenase 2

Cutaneous and Systemic Mastocytosis

TFG

3q12.2

TRK-fused gene

Primary Cutaneous Anaplastic Large Cell Lymphoma

TPM3

1q21.2

tropomyosin 3

Primary Cutaneous Anaplastic Large Cell Lymphoma

TPM4

19p13.1

tropomyosin 4

Primary Cutaneous Anaplastic Large Cell Lymphoma

Trisomy 21

21

Angioimmunoblastic T-cell Lymphoma

Trisomy 3

3

Angioimmunoblastic T-cell Lymphoma

Trisomy 5

5

Angioimmunoblastic T-cell Lymphoma

Trisomy 6

6

Primary Neuroendocrine (Merkel Cell) Carcinoma

TSC1

9q34

tuberous sclerosis 1

Acral Fibrokeratoma; Angiofibroma and Related Lesions; PEComas

TSC2

16p13.3

tuberous sclerosis 2

Acral Fibrokeratoma; Angiofibroma and Related Lesions; PEComas

VEGFR3

5q35.3

FLT4

Lymphangioma and Superficial Lymphangioma

X, gain of

X

Angioimmunoblastic T-cell Lymphoma; Systemic T-cell and NK-cell Lymphomas Involving the Skin

X, inactivation of

X

Neurofibroma