Makes a Cannabis Variety and Why it’s Important



WHAT MAKES A CANNABIS VARIETY AND WHY IT’S IMPORTANT


Different cannabis varieties produce different medicinal effects, owing to unique variations in the chemistry produced by each individual variety. The medicinal effects can vary so dramatically among cannabis varieties that each one can effectively become a different medicine. Some cannabis varieties produce THC, while others produce CBD; some produce nearly equal amounts of both cannabinoids. Variation in terpene content also significantly modifies the medicinal effects of cannabis varieties.


Narrow-leafleted THC cannabis varieties were likely introduced to the Western Hemisphere by indentured laborers from India, when the British transported these Indian workers to Jamaica in the 1830s. The major expansion of cannabis varieties in the West did not begin until marijuana breeding became more widespread in the 1960s, however. In 2009, CBD-rich varieties were identified in the United States and the use of these CBD cannabis varieties could eventually spark another medical cannabis breeding revolution.


Name Games and Strain Identification


Pick up any alternative newspaper in San Francisco, Denver, or Los Angeles, and you’ll see advertisements for G13 Kush, Blue Lightning, Charlie Sheen Kush, Obama Cookies, and so on. There are hundreds of medical marijuana varieties being marketed by storefront dispensaries and delivery services. The average person looks at this and thinks, “Where do they get these ridiculous names?” The answer is that they’re made up. Then again, someone made up the name “Google,” too.


The more important question about these medical marijuana varieties is: If the names are just made up, what are the chemically distinct varieties of cannabis that these companies claim to be selling? The fact of the matter is that nobody really knows, including the folks selling them. This ignorance is usually not malicious, and cultivators do try to make informed guesses as to the identities of the cannabis varieties they provide. But there aren’t many standards or certification procedures in California or Colorado—although that is changing.


In 2013, legislation was introduced in Connecticut to regulate medical cannabis, and it requires products to have brand names. As a result of this, each batch of the cannabis product must fall within a tight chemical tolerance based on its initial product specification registered with the state, or it loses the right to the product name.



Cannabis varieties can be chemically and genetically fingerprinted to identify them with precision. Chemical fingerprinting determines the normal range of terpenoids and cannabinoids produced by a specific phenotype of a single cannabis variety. For example, one phenotype of OG Kush when cultivated under consistent conditions will produce 24 percent THCA, 0.8 percent CBD, 1.6 percent myrcene, 0.9 percent alpha-pinene, 0.7 percent limonene, and 0.8 percent beta-caryophyllene. These numbers comprise the pharmacologically active chemical fingerprint of this OG Kush. The genetic fingerprint of the same OG Kush phenotype could be the genes that control the plant’s manufacture of these pharmacologically active substances. Each variety of cannabis contains genes that determine its specific chemical composition. The production of each essential oil and each cannabinoid by the plant is controlled by the expression of genes.


Optimization of a cannabis variety’s ability to produce pharmacologically interesting substances requires this kind of fingerprinting to understand what each cannabis variety is capable of producing. This kind of understanding and precision is used for all kinds of herbs, spices, and produce on the market. Soon, it will be used for medical cannabis as well. With uniform product names will also come consistent composition and manufacture of herbal cannabis medicines. So the next Charlie Sheen Kush will be exactly the same as the last Charlie Sheen Kush . . . and they may have to pay a royalty to the actual Charlie Sheen, if he’ll grant that right. One part of the great guessing game of medical cannabis will end. Others will remain.


The biggest mystery of modern cannabis is why varieties of cannabis produce different medicinal or psychoactive effects. While it is clear that these effects are profoundly influenced by the ratios of cannabinoids and terpenoids that are unique to each variety, the results of the interactions of these terpenoids and cannabinoids is extremely complex and still not completely understood. Through emerging approaches, such as principal component analysis of cannabis, an exploratory data analysis technique that helps scientists understand the complex interactions of multiple plant constituents, it will become possible to predict the effects of a cannabis variety more accurately, by mapping its chemistry precisely and understanding the interactions that arise because of that chemistry.


From Landrace Varieties and Adaptation to Modern Breeding


There are thousands of cannabis varieties from Korea to Mexico, from Uruguay to Malawi. All across Russia, Kazakhstan, Nepal . . . Cannabis is everywhere and everywhere each strain is different, slightly adapted to each specific locale. Individual varieties are called landraces—a term used to define the local variations of the cannabis plant. And it is from these landraces that modern medical cannabis varieties have been bred. In a few cases, such as Malawi Gold, the landrace has not been bred with another variety. For this unique strain, the plant remains exactly as found near villages along the banks of Lake Malawi in Africa.


In the 1960s, as illicit cannabis use increased in Western countries, hippie backpackers visited regions of the world where native varieties of cannabis could be found. Mexico, Jamaica, Colombia, Morocco, southern Africa, Lebanon, Turkey, Afghanistan, Pakistan, Nepal, India, and Thailand all produced landrace varieties that were brought back to form the genetic pool from which modern cannabis was bred. This illicit “bioprospecting”—searching for local plant species of medicinal value, is actually prohibited in many of these countries today, because the landrace plants are now considered strategic national assets.


Most medical cannabis varieties in use today have been crossed to yield new varieties. They are descended from landraces, certainly, but the majority of them likely bear little resemblance to their ancestors. These new varieties have been chosen and bred for one thing: their ability to produce THC. And while this has made for some extraordinarily psychoactive varieties, it has also resulted in highly inbred cannabis. Marijuana from around the world exhibits some fascinating natural diversity, while modern, medical cannabis contains very little that is unique and quite a bit that is identical. In a word, these varieties are invariably cut from the same cloth.


Prohibition of cannabis has ensured that we know very little of the composition or ancestry of many pre-1965 varieties. And what we do know is often impossible to confirm. There are a lot of egos and faulty memories involved, as well as more than a little arrogance. Consider the legendary Santa Cruz variety called Haze—a foundation strain in modern cannabis breeding that has been used to breed dozens, if not hundreds, of varieties of cannabis. David Paul Watson, a.k.a. Sam the Skunkman, a.k.a. Jingles, claims to have introduced Haze to the Netherlands in the 1980s and his claim is well supported. The Australian cannabis breeder, Neville Schoenmaker, a.k.a. Nevil, claims to have visited Santa Cruz himself, where he met the legendary Haze Brothers, who then gave him the variety. The actual story of Haze, the foundation of modern cannabis breeding, remains obscure. Those who know believe that Haze was more luck than skill. The only remaining evidence of the Haze project is a poster printed in 1976 in Santa Cruz signed “R.L.,” discussing grow tips observed in its production. Sifting the truth from the legends is impossible.


When it comes to the genetics of a particular variety, we often don’t know what landraces were used to breed it, or whether said variety is anything more than an inbred mess with a big THC spike. Modern scientific testing has started to unravel the mysteries of how cannabis makes its constituents and, increasingly, which genes control the process. Soon we should be able to breed cannabis to suit our tastes and medicinal needs perfectly. Today’s present mess will fade away. And from the remaining landraces and high-quality varieties we will create the next generation of medical cannabis. Breeders have been toiling away for decades, trying to improve the cannabis plant’s ability to produce medicine. Some of the most successful efforts follow.


There may be an occasion on which a breed of cannabis is designed to smell good or look attractive—but at the end of the day, it all comes down to cannabinoid and terpene content, and the cleanliness of the cultivation.


Selecting a Medical Cannabis Variety


The common descriptors used at dispensaries, indica and sativa, rarely determine anything beyond the most basic medicinal effects. Typically, indica is used to describe broad-leafleted varieties that produce terpenes such as myrcene and linalool. More sedating, they produce more lethargic “stone.” Sativa characterizes narrow-leafleted varieties that produce terpenes such as caryophyllenes and pinenes, which are stimulating and tend to produce more of a cerebral “high.” Selecting precisely the appropriate variety of medical cannabis requires an understanding of the variety’s basic genetics and chemistry beyond simplistic indica and sativa designations.


The basics of cannabis chemistry manifest themselves in a variety’s appearance and aroma. Certain aromas produced by cannabis provide a surprisingly reliable indication of the variety’s effects. A piney scent is indicative of stimulating results. A lavender or grape aroma typically is associated with sedative varieties. Learn how to associate cannabis aroma with cannabis effects and you’ll become informed very quickly.


But judging cannabis simply by its variety name remains a gamble. There is a great deal of fraud, and even more innocent ignorance. For example, nobody really knows what varieties bred OG Kush. So what is real OG Kush? More importantly, what are the genetics and chemistry that make OG Kush an effective medicine? There are stories of the origin of OG—they may or may not be true. But they always run out of rope. Some say that OG Kush’s parent first showed up as a seed in a bag of Chemdawg cannabis at a Grateful Dead concert. OK, but then what varieties bred the cannabis seed in that bag? No answer. Is this Chem ’91 a version of some amazing Colorado variety? Or a Nepalese Thai cross? Or a landrace from Afghanistan? Nobody knows. What is known for certain is that OG Kush is a tall, broad-leafleted hybrid that typically produces upward of 20 percent THC and has an intense aroma of pine, citrus, and fuel.


Once you establish consistency in the varieties available to you, it’s easier to decide among them. Simple, right? You just need to find someone who pays attention to their cannabis and looks for repeatable patterns in its structure and chemistry. Those patterns are definitely there, and with the help of laboratory instruments—which take precise measurements of your cannabis product’s constituent elements—the uniqueness of your preferred medical variety may be revealed.


The following patterns and observations can help you determine the most suitable medical cannabis variety for the course of treatment recommended by your physician.


Modern Cannabis Varieties


The following pages consider 27 modern cannabis varieties and their medicinal properties. The locations in which they are grown are indicated on this map, as well as each variety’s species type, whether indica, sativa, or hybrid.


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Jun 24, 2016 | Posted by in PHARMACY | Comments Off on Makes a Cannabis Variety and Why it’s Important

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