Keloid and Cellular Scar

Keloid and Cellular Scar

David S. Cassarino, MD, PhD

Low-power examination shows a polypoid skin lesion with dense dermal collagen. Note the mild epidermal hyperplasia. Commonly the epidermis overlying a keloid scar is atrophied.

Hematoxylin & eosin shows the superficial aspect of the lesion. Note the dermal scarring with telangiectasia and prominent hyalinized collagen bundles.



  • Scar with keloidal collagen


  • Scar with prominent thickened and eosinophilic bundles of collagen extending beyond original wound


Unknown, Possibly Genetic

  • Fibroblasts from keloids show decreased apoptosis

  • Many cytokines implicated in stimulating fibroblasts, including TGF-β1 and IL-15



  • Age

    • Most common in patients < 30 years

  • Ethnicity

    • More common in black patients; least common in Caucasians


  • Earlobe is most common site

    • Typically follows ear piercing or other trauma by a few months

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Keloid and Cellular Scar
Premium Wordpress Themes by UFO Themes
%d bloggers like this: