Keloid and Cellular Scar



Keloid and Cellular Scar


David S. Cassarino, MD, PhD









Low-power examination shows a polypoid skin lesion with dense dermal collagen. Note the mild epidermal hyperplasia. Commonly the epidermis overlying a keloid scar is atrophied.






Hematoxylin & eosin shows the superficial aspect of the lesion. Note the dermal scarring with telangiectasia and prominent hyalinized collagen bundles.


TERMINOLOGY


Synonyms



  • Scar with keloidal collagen


Definitions



  • Scar with prominent thickened and eosinophilic bundles of collagen extending beyond original wound


ETIOLOGY/PATHOGENESIS


Unknown, Possibly Genetic



  • Fibroblasts from keloids show decreased apoptosis


  • Many cytokines implicated in stimulating fibroblasts, including TGF-β1 and IL-15


CLINICAL ISSUES


Epidemiology



  • Age



    • Most common in patients < 30 years


  • Ethnicity



    • More common in black patients; least common in Caucasians


Site



  • Earlobe is most common site



    • Typically follows ear piercing or other trauma by a few months

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Keloid and Cellular Scar
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