Intestinal-type Adenoma
Vikram Deshpande, MD
Key Facts
Terminology
Gallbladder polyp composed of intestinal-type epithelium
Clinical Issues
Progression to carcinoma uncommon
Microscopic Pathology
Resemble colonic adenomas
Tubular, papillary to mixed tubulopapillary patterns
Ancillary Tests
MUC2: Diffusely positive
Mutations in β-catenin present
P53 mutations virtually absent
Top Differential Diagnoses
Pyloric-type adenoma
Invasive adenocarcinoma
 This lobulated intraluminal polypoidal adenoma of the gallbladder  was associated with chronic cholecystitis and gallstones  , as are the majority of intestinal-type adenomas. |
 This tubulopapillary intestinal-type adenoma is composed of intestinal-type epithelium that resembles an adenoma of the colon. |
TERMINOLOGY
Definitions
Gallbladder polyp predominantly composed of intestinal-type epithelium
ETIOLOGY/PATHOGENESIS
Unknown
Associated with chronic cholecystitis and cholelithiasis
CLINICAL ISSUES
Epidemiology
Incidence
Low: 0.3-0.5% of cholecystectomy specimens
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
