interactions

Herb/nutrient-drug interactions



NOTES



ASSUMPTIONS


The following assumptions were made when collating and assessing information for this table:


• The clinical significance of many interactions is still unknown because controlled trials are lacking in most cases. In these instances, interactions are based on evidence of pharmacological activity and case reports, and have a sound theoretical basis, although remain to be tested.

• All information refers to oral dose forms unless otherwise specified.

• Information is correct at the time of writing; however, because of the ever-expanding knowledge base developing in this area, new research is constantly being published.

• The interaction table is provided as a guide only and should not replace the use of professional judgment. It has been developed to assist clinicians when advising patients.


USING THIS GUIDE IN PRACTICE



• Commonly used prescription and over-the-counter medications are organised by therapeutic class and subclass and are listed alphabetically.

• Common names have been used when referring to herbs.


RECOMMENDATIONS


Avoid—There may be insufficient information available to be able to advise using the two substances safely together, so avoid until more is known. The drug may have a narrow therapeutic index and there is sufficient evidence to suggest that the interaction may be clinically significant. Consider an alternative treatment that is unlikely to produce an undesirable interaction.


Avoid use unless under medical supervision—Harmful effects of the potential interaction can be avoided if doses are altered appropriately under professional supervision or the patient is closely monitored. Some of these interactions can be manipulated to the advantage of the patient. Changes to the dosage regimen may be required for safe combined use.


Exercise caution—The possibility exists of an interaction that may change effects clinically; be aware and monitor. It is prudent to tell patients to be aware and seek advice if they are concerned.


Observe—Interaction may not be clinically significant at the usual recommended doses and may be theoretical; however, the clinician should be alert to the possibility of an interaction.


Beneficial interaction possible—Prescribing the interacting substance may improve clinical outcomes; for example, reducing drug requirements, complementing drug effects, reducing drug side effects, counteracting nutritional deficiencies caused by drugs, alleviating drug withdrawal symptoms, and enhancing patient wellbeing.




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Oct 1, 2016 | Posted by in GENERAL SURGERY | Comments Off on interactions

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