These are the preferred pumps for medium- and large-volume infusions, although some are designed specifically to operate at low flow rates for neonatal use. The rate is selected in millilitres per hour (usual range 1–999 mL/hour). Typically, most volumetric pumps are accurate to ±5% at rates down to 5 mL/hour. A syringe pump should be used for rates lower than 5 mL/hour. Volumetric pumps require the use of an administration set matched to the pump.

Volumetric pumps are used to administer a wide range of fluids and medicines, including standard hydration fluids such as sodium chloride 0.9%, medicines that need administration at a controlled rate, such as iron sucrose complex (Venofer), and intravenous nutrition.