HPV-related Epidermal Cyst
Elsa F. Velazquez, MD
David Cassarino, MD, PhD
Key Facts
Etiology/Pathogenesis
-
HPV-related cysts
-
Verrucous cysts have been reported to be associated with HPV-20 and -34
-
Epidermoid cyst of the palm and sole is associated with HPV-60 and -57 (affects Japanese)
-
Microscopic Pathology
-
Verrucous epidermal cyst
-
Papillary and acanthotic squamous epithelium with hypergranulosis and hyperkeratosis (focal parakeratosis)
-
Keratohyalin granules
-
Koilocytic change
-
-
Epidermoid cyst of the palm and sole
-
Epidermis-like lining
-
Eosinophilic intracytoplasmic inclusions in wall
-
Vacuolated cells in keratin contents
-
Verrucous epidermal cyst shows an acanthotic and papillated epithelial structure in the dermis. Note the separation from the epidermis  . |
High magnification shows the acanthotic epithelium of an HPV-related verrucous epidermal cyst showing prominent keratohyaline granules  and koilocytosis  . |
TERMINOLOGY
Synonyms
-
Verrucous cyst, epidermoid cyst of the palm and sole
Definitions
-
Epidermoid cysts associated with human papillomavirus (HPV) infection
ETIOLOGY/PATHOGENESIS
Infectious Agents
-
Human papillomaviruses (HPV)
-
Verrucous cysts have been reported to be associated with HPV-20 and -34 (epidermodysplasia verruciformis strains)
-
Epidermoid cyst of the palm and sole mainly associated with HPV-60 and -57
-
Traumatic implantation of HPV-infected epidermis (or perhaps eccrine ducts) into dermis
-
-
CLINICAL ISSUES
Full access? Get Clinical Tree
