A large number of lung diseases, of varying etiologies, exhibit the same end-stage fibrotic pattern of honeycomb lung. Diseases that have honeycomb lung as an end-stage pattern include usual interstitial pneumonia and other idiopathic interstitial pneumonias, asbestosis and other pneumonconioses, chronic infections, bronchiectasis, chronic aspiration, sarcoidosis, chronic hypersensitivity pneumonitis, diffuse alveolar damage, and drug reactions, among other chronic lung diseases. Grossly, a honeycomb lung is shrunken and multinodular, likened to a cirrhotic liver. Cut section shows replacement of normal architecture with variably sized cysts with surrounding fibrous stoma.