Hibernoma



Hibernoma


Khin Thway, BSc, MBBS, FRCPath









Hematoxylin & eosin shows low-power view of hibernoma, composed of well-defined lobules of polygonal cells. Cells with the appearance of brown fat are mixed with mature adipocytes. No atypia is present.






Hematoxylin & eosin shows hibernoma at higher magnification, composed of an admixture of polygonal cells with granular eosinophilic or multivacuolated cytoplasm. Univacuolated adipocytes are also seen.


TERMINOLOGY


Synonyms



  • Fetal lipoma, lipoma of embryonic fat


Definitions



  • Benign tumor most frequently occurring in younger adults, with differentiation toward brown fat



    • Tumor has characteristic cytogenetic aberrations, mainly involving 11q13-21


ETIOLOGY/PATHOGENESIS


Developmental Anomaly



  • Etiology unknown



    • Many occur at sites of normal brown fat in fetuses and newborns


    • Genetic changes in some


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare; approximately 1% of all adipocytic tumors


  • Age



    • Peak incidence: 3rd decade


    • Rare in children


  • Gender



    • M = F

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Hibernoma
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