Chapter 16 Hematology
Heparins
Description
Heparin belongs to a family of endogenous substances known as glycosaminoglycans (GAGs). Heparin and its synthetic derivatives are anticoagulants.
MOA (Mechanism of Action)






Pharmacokinetics
Unfractionated Heparin



Indications

Side Effects

Important Notes





Evidence
LMWH versus Warfarin for Treatment of Venous Thromboembolism

LMWH and Heparinoids versus UFH for Ischemic Stroke

Direct Factor Xa Inhibitors
Description
Direct factor Xa inhibitors are agents that inhibit clotting by inhibiting a specific component of the coagulation cascade.
MOA (Mechanism of Action)







Pharmacokinetics

Important Notes

Advanced
Drug Interactions

Evidence
Postsurgical Venous Thromboembolism Prophylaxis

FYI

Direct Thrombin Inhibitors
Description
Direct thrombin inhibitors reduce clotting by inhibiting a specific component of the coagulation cascade.
MOA (Mechanism of Action)









Pharmacokinetics

Important Notes



Vitamin K Antagonists
Description
Vitamin K antagonists are a family of naturally derived anticoagulants, which are also known as coumarins.
MOA (Mechanism of Action)




Pharmacokinetics

Indications

Important Notes





Evidence
Warfarin versus LMWH for Treatment of Venous Thromboembolism

Warfarin versus Acetylsalicylic Acid for Atrial Fibrillation

Salicylates
Description
Salicylates comprise a heterogeneous group of agents that are related by chemical structure and by their antiinflammatory effects.
Prototype and Common Drugs
Salicylates

MOA (Mechanism of Action)
Salicylates



Full access? Get Clinical Tree

