Glomeruloid Hemangioma
David Cassarino, MD, PhD
Key Facts
Terminology
Glomeruloid angioma
Etiology/Pathogenesis
Association with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) or multicentric Castleman syndrome in most cases
Clinical Issues
More common in Asians (especially Japanese)
Multiple red to purple eruptive papules (POEMS syndrome)
Microscopic Pathology
Vessels show distinctive grape-like clusters, mimicking renal glomeruli
Endothelial cells are mildly enlarged and many show cytoplasmic eosinophilic globules
Cytoplasmic globules (immunoglobulins) are PAS(+)
 Low magnification shows a superficial dermal proliferation of small clusters of vessels with a glomeruloid pattern. |
 High-power view of a glomeruloid hemangioma shows small, grape-like clusters of vessels projecting into vascular lumina (with peripheral crescentic spaces  ). |
TERMINOLOGY
Abbreviations
Glomeruloid hemangioma (GH)
Synonyms
Glomeruloid angioma
Definitions
Benign proliferation of small vessels mimicking renal glomeruli
ETIOLOGY/PATHOGENESIS
Paraneoplastic Syndrome
Association with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) or multicentric Castleman disease in almost all cases
Unknown
Rare cases not associated with POEMS syndrome
CLINICAL ISSUES
