Giant Cell Angiofibroma
Amitabh Srivastava, MD
Key Facts
Terminology
Benign fibroblastic tumor with multinucleated tumor giant cells and angiectoid spaces
May be related to solitary fibrous tumor/hemangiopericytoma group
Clinical Issues
Lesion of middle-aged adults; often involves orbit
Extraorbital lesions predominate in women
Does not recur following complete surgical excision
Microscopic Pathology
Bland spindle to round cell proliferation with variable cellularity
Prominent angiectoid spaces; cystic change and hemorrhage
Multinucleated stromal cells around angiectoid spaces
Tumor cells are CD34(+) and CD99(+)
 Giant cell angiofibromas are well-circumscribed tumors. The lesion shown here is sharply demarcated from skeletal muscle  . Scattered larger nuclei are discernible at low-power examination  . |
 Hypocellular  and hypercellular  areas with ectatic pseudovascular spaces  are present in giant cell angiofibroma. |
TERMINOLOGY
Abbreviations
Giant cell angiofibroma (GCAF)
Definitions
Benign fibroblastic tumor with multinucleated tumor giant cells and angiectoid spaces
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