Class
- Cholinesterase inhibitor
Galantamine
Commonly Prescribed for
(FDA approved in bold)
- Alzheimer dementia (AD) (mild or moderate)
- Dementia with Lewy Bodies (DLB)
- Vascular dementia
Galantamine
How the Drug Works
- Increases the concentration of acetylcholine through reversible inhibition of metabolism by acetylcholinesterase enzyme, which increases availability of acetylcholine. A deficiency of cholinergic function is felt to be important in producing the signs and symptoms of AD
- May also modulate nicotine receptors, increasing acetylcholine release
- May interfere with amyloid deposition
- Although symptoms of AD can improve, galantamine does not prevent disease progression
Galantamine
How Long Until It Works
- Typically 2–6 weeks at a given dose, but effect is best observed over a period of months
Galantamine
If It Works
- Continue to use but symptoms of dementia usually worsen over time
Galantamine
If It Doesn’t Work
- Change to another cholinesterase inhibitor or NMDA-antagonist (memantine)
- Non-pharmacologic measures are the basis of dementia treatment. Maintain regular schedules and routines. Avoid prolonged travel, unnecessary medical procedures or emergency room visits, crowds, and large social gatherings
- Limit drugs with sedative properties such as opioids, hypnotics, antiepileptic drugs and tricyclic antidepressants
- Treat other disorders which can worsen symptoms such as hyperglycemia or urinary difficulties
Galantamine
Best Augmenting Combos for Partial Response or Treatment-Resistance
- Addition of the NMDA receptor antagonist memantine may be useful
- Treat depression or apathy, if present, with SSRIs. Avoid tricyclic antidepressants in demented patients due to risk of confusion
- For significant confusion and agitation avoid neuroleptics (especially in Lewy Body dementia) because of the risk of neuroleptic malignant syndrome. Atypical antipsychotics (risperidone, quetiapine, olanzapine, clozapine) can be used instead
Galantamine
Tests
- None required
Adverse Effects (AEs)
Galantamine
How Drug Causes AEs
- Acetylcholinesterase inhibition in the CNS and PNS
Galantamine
Notable AEs
- GI AEs (nausea/vomiting, diarrhea, anorexia and weight loss) are most common. Fatigue, headache, and dizziness
Galantamine
Life-Threatening or Dangerous AEs
- Rarely bradycardia or heart block, causing syncope
Galantamine
Weight Gain
- Unusual
- Weight loss is more common
Galantamine
Sedation
- Unusual
Galantamine
What to Do About AEs
- In patients with dementia, determining if AEs are related to medication or another medical condition can be difficult. For CNS side effects, discontinuation of non-essential centrally acting medications may help. If a bothersome AE is clearly drug-related then lower the dose (especially for GI AEs), titrate more slowly or discontinue