Fundic Gland Polyp
Gregory Y. Lauwers, MD
Key Facts
Terminology
Benign cystic and polypoid transformation of oxyntic mucosa
Etiology/Pathogenesis
Sporadic
Familial adenomatous polyposis
Proton pump inhibitor
Zollinger-Ellison syndrome
Clinical Issues
Common type of gastric polyp
Solitary or multiple polypoid lesions
Limited to body/fundus
Surveillance important in setting of FAP
Macroscopic Features
Usually 1-2 mm
 Endoscopic photograph shows a typical fundic gland polyp. The lesion is solitary, smooth, and sessile. |
 Hematoxylin & eosin shows the benign cystic and polypoid hyperplastic oxyntic glands that are characteristic of fundic gland polyps. |
TERMINOLOGY
Abbreviations
Fundic gland polyp (FGP)
Synonyms
Elster glandular cysts
Fundic gland hyperplasia
Cystic hamartomatous epithelial polyp
Definitions
Benign cystic and polypoid lesion of hyperplastic oxyntic glands, including mucous neck cells
ETIOLOGY/PATHOGENESIS
Various Etiologies
Sporadic
Familial adenomatous polyposis (FAP)
Proton pump inhibitor
Zollinger-Ellison syndrome
Biology
Alterations of APC-β-catenin pathway in both sporadic and syndromic FGPs
Present in dysplastic and nondysplastic polyps
Activating somatic mutations of exon 3 of β-catenin gene detected in most sporadic FGPs
Germline APC mutations or 5q allelic loss detected in most syndromic FGPs
CLINICAL ISSUES
Epidemiology
