Fibrous Hamartoma of Infancy
Khin Thway, BSc, MBBS, FRCPath
Key Facts
Terminology
Benign superficial fibrous lesion occurring during 1st 2 years of life
Clinical Issues
Congenital in up to 25%
M > F
Occur in deep dermis or subcutis
Typically in upper torso but at variety of sites
Complete excision is curative
Can recur if incompletely excised
Microscopic Pathology
3 components in organoid growth pattern
Intersecting bands of mature fibrous tissue, comprising spindle myofibroblasts and fibroblasts
Nests of immature round, ovoid, or spindle cells in myxoid stroma
Interspersed mature fat
 Hematoxylin & eosin shows fibrous hamartoma of infancy. The lesion is poorly defined, with nodules of rounded to ovoid cells  and fibrous bands of spindle cells  admixed with mature fat. |
 Hematoxylin & eosin shows fibrous hamartoma of infancy. Nodules of immature round to ovoid cells  , situated within mature adipose tissue  , abut the fibrous trabeculae  . |
TERMINOLOGY
Abbreviations
Fibrous hamartoma of infancy (FHI)
Definitions
