Cyril Fisher, MD, DSc, FRCPath

Low magnification shows a typically cellular low-grade fibrosarcoma with uniform spindle cells arranged in long intersecting fascicles in a so-called herringbone pattern. No necrosis is seen.

This well-differentiated fibrosarcoma shows uniform tapered spindle cells. The nuclei are elongated, and some have a small nucleolus.



  • Soft tissue sarcoma of adults composed of fibroblasts

  • Lacks features of specific fibrosarcoma subtypes, which may be found in dermis/subcutis

    • Low-grade fibromyxoid sarcoma

    • Myxofibrosarcoma

    • Infantile fibrosarcoma

      • Has t(12;15)(p13;q26) with ETV6-NTRK3 fusion

  • Now very rare; mostly a diagnosis of exclusion

  • Pleomorphic variants are currently classified as undifferentiated sarcoma/malignant fibrous histiocytoma

  • Conclusive diagnosis can require electron microscopy


De Novo

  • Exceptionally rare if strictly defined

Arising in Association with Other Tumors

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Fibrosarcoma

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